effect of M‐phase stage‐dependent kinase inhibitors on inositol 1,4,5‐trisphosphate receptor 1 (IP3R1) expression and localization in pig oocytes

At fertilization, inositol 1,4,5‐trisphosphate receptor type 1 (IP₃R1) has a crucial role in Ca²⁺release in mammals. Expression levels, localization and phosphorylation of IP₃R1 are important for its function, but it still remains unclear which molecule(s) regulates IP₃R1 behavior in pig oocytes. We...

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Veröffentlicht in:	Animal science journal 2015-02, Vol.86 (2), p.138-147
Hauptverfasser:	Sathanawongs, Anucha, Fujiwara, Katsuyoshi, Kato, Tsubasa, Hirose, Masahiko, Kamoshita, Maki, Wojcikiewicz, Richard J. H, Parys, Jan B, Ito, Junya, Kashiwazaki, Naomi
Format:	Artikel
Sprache:	eng
Schlagworte:	5-trisphosphate receptor Animals Butadienes - pharmacology Calcium - metabolism Cell Cycle Proteins - antagonists & inhibitors Cell Cycle Proteins - physiology Cells, Cultured cortex Cyclin-dependent kinases dose response Dose-Response Relationship, Drug Gene Expression - drug effects Hogs inositol 1 Inositol 1,4,5-Trisphosphate Receptors - genetics Inositol 1,4,5-Trisphosphate Receptors - metabolism Inositol 1,4,5-Trisphosphate Receptors - physiology inositols Kinases maturation Mice mitogen-activated protein kinase Nitriles - pharmacology oocyte oocytes Oocytes - metabolism Phosphorylation Phosphorylation - drug effects pig Polo-Like Kinase 1 Protein Kinase Inhibitors - pharmacology Protein Serine-Threonine Kinases - antagonists & inhibitors Protein Serine-Threonine Kinases - physiology Proto-Oncogene Proteins - antagonists & inhibitors Proto-Oncogene Proteins - physiology Pteridines - pharmacology Purines - pharmacology Roscovitine swine Swine - metabolism
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