effect of M‐phase stage‐dependent kinase inhibitors on inositol 1,4,5‐trisphosphate receptor 1 (IP3R1) expression and localization in pig oocytes
At fertilization, inositol 1,4,5‐trisphosphate receptor type 1 (IP₃R1) has a crucial role in Ca²⁺release in mammals. Expression levels, localization and phosphorylation of IP₃R1 are important for its function, but it still remains unclear which molecule(s) regulates IP₃R1 behavior in pig oocytes. We...
Gespeichert in:
| Veröffentlicht in: | Animal science journal 2015-02, Vol.86 (2), p.138-147 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 147 |
|---|---|
| container_issue | 2 |
| container_start_page | 138 |
| container_title | Animal science journal |
| container_volume | 86 |
| creator | Sathanawongs, Anucha Fujiwara, Katsuyoshi Kato, Tsubasa Hirose, Masahiko Kamoshita, Maki Wojcikiewicz, Richard J. H Parys, Jan B Ito, Junya Kashiwazaki, Naomi |
| description | At fertilization, inositol 1,4,5‐trisphosphate receptor type 1 (IP₃R1) has a crucial role in Ca²⁺release in mammals. Expression levels, localization and phosphorylation of IP₃R1 are important for its function, but it still remains unclear which molecule(s) regulates IP₃R1 behavior in pig oocytes. We examined whether there was a difference in localization of IP₃R1 after in vitro or in vivo maturation of pig oocytes. In mouse oocytes, large clusters of IP₃R1 were formed in the cortex of the oocyte except in a ring‐shaped band of cortex adjacent to the spindle. However, no such clusters of IP₃R1 were observed in pig oocytes and there was no difference in its localization between in vitro and in vivo matured oocytes. We next tried to clarify which factor(s) regulates IP₃R1 localization, phosphorylation and expression using M‐phase stage‐dependent kinase inhibitors. Our results show that treatments with roscovitine (p34ᶜᵈᶜ²kinase inhibitor) or U0126 (mitogen‐activated protein kinase inhibitor) did not affect IP₃R1 expression or localization in pig oocytes, although the latter strongly inhibited phosphorylation. However, treatment with BI‐2536, an inhibitor of polo‐like kinase 1 (Plk1), dramatically decreased the expression level of IP₃R1 in pig oocytes in a dose‐dependent manner. From these results, it is suggested that Plk1 is involved in the regulation of IP₃R1 expression in pig oocytes. |
| doi_str_mv | 10.1111/asj.12258 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_1648547699</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3570867091</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4908-9d6005db4e6c7b7279a5f26688fd81345b9bc57bfe1c6bcd256ac53155b958353</originalsourceid><addsrcrecordid>eNp1kc9O3DAQxqOqVaG0h75Aa4lLkQjYSfzviFChoC1UUMrRcpzJrpcQp7ZXsD31EXrr-_EkeAlww5LlGc1vvpHny7KPBO-QdHZ1mO-QoqDiVbZOeIVzLAv5OsVlVeWlrMha9i6EOcaES0zfZmsFJYITwtaz_9C2YCJyLfp-9_ffMNMBUIh6CilrYIC-gT6iK9uvCraf2dpG5wNyfcpcSEmHyHa1TRMfvQ3DzKWrIyAPBobEIoK-HP0oz8gWgtvBQwg2Neu-QZ0zurN_dLQPamiwU-ScWUYI77M3re4CfHh8N7KLg68_97_lk9PDo_29SW4qiUUuG4YxbeoKmOE1L7jUtC0YE6JtRPo-rWVtKK9bIIbVpiko04aWhKYCFSUtN7LNUXfw7vcCQlRzt_B9GqkIqwStOJMyUVsjZbwLwUOrBm-vtV8qgtXKApUsUA8WJPbTo-KivobmmXzaeQJ2R-DGdrB8WUntnR8_SeZjhw0Rbp87tL9SjJecqsuTQzU5Zmcnl7-EWk34PPKtdkpPkyvq4rzAJO2KYMpFUd4DEeCsAg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1648547699</pqid></control><display><type>article</type><title>effect of M‐phase stage‐dependent kinase inhibitors on inositol 1,4,5‐trisphosphate receptor 1 (IP3R1) expression and localization in pig oocytes</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><source>Alma/SFX Local Collection</source><creator>Sathanawongs, Anucha ; Fujiwara, Katsuyoshi ; Kato, Tsubasa ; Hirose, Masahiko ; Kamoshita, Maki ; Wojcikiewicz, Richard J. H ; Parys, Jan B ; Ito, Junya ; Kashiwazaki, Naomi</creator><creatorcontrib>Sathanawongs, Anucha ; Fujiwara, Katsuyoshi ; Kato, Tsubasa ; Hirose, Masahiko ; Kamoshita, Maki ; Wojcikiewicz, Richard J. H ; Parys, Jan B ; Ito, Junya ; Kashiwazaki, Naomi</creatorcontrib><description>At fertilization, inositol 1,4,5‐trisphosphate receptor type 1 (IP₃R1) has a crucial role in Ca²⁺release in mammals. Expression levels, localization and phosphorylation of IP₃R1 are important for its function, but it still remains unclear which molecule(s) regulates IP₃R1 behavior in pig oocytes. We examined whether there was a difference in localization of IP₃R1 after in vitro or in vivo maturation of pig oocytes. In mouse oocytes, large clusters of IP₃R1 were formed in the cortex of the oocyte except in a ring‐shaped band of cortex adjacent to the spindle. However, no such clusters of IP₃R1 were observed in pig oocytes and there was no difference in its localization between in vitro and in vivo matured oocytes. We next tried to clarify which factor(s) regulates IP₃R1 localization, phosphorylation and expression using M‐phase stage‐dependent kinase inhibitors. Our results show that treatments with roscovitine (p34ᶜᵈᶜ²kinase inhibitor) or U0126 (mitogen‐activated protein kinase inhibitor) did not affect IP₃R1 expression or localization in pig oocytes, although the latter strongly inhibited phosphorylation. However, treatment with BI‐2536, an inhibitor of polo‐like kinase 1 (Plk1), dramatically decreased the expression level of IP₃R1 in pig oocytes in a dose‐dependent manner. From these results, it is suggested that Plk1 is involved in the regulation of IP₃R1 expression in pig oocytes.</description><identifier>ISSN: 1344-3941</identifier><identifier>EISSN: 1740-0929</identifier><identifier>DOI: 10.1111/asj.12258</identifier><identifier>PMID: 25187116</identifier><language>eng</language><publisher>Australia: Japanese Society of Zootechnical Science, Jan. 1999-<Apr. 2003></publisher><subject>5-trisphosphate receptor ; Animals ; Butadienes - pharmacology ; Calcium - metabolism ; Cell Cycle Proteins - antagonists & inhibitors ; Cell Cycle Proteins - physiology ; Cells, Cultured ; cortex ; Cyclin-dependent kinases ; dose response ; Dose-Response Relationship, Drug ; Gene Expression - drug effects ; Hogs ; inositol 1 ; Inositol 1,4,5-Trisphosphate Receptors - genetics ; Inositol 1,4,5-Trisphosphate Receptors - metabolism ; Inositol 1,4,5-Trisphosphate Receptors - physiology ; inositols ; Kinases ; maturation ; Mice ; mitogen-activated protein kinase ; Nitriles - pharmacology ; oocyte ; oocytes ; Oocytes - metabolism ; Phosphorylation ; Phosphorylation - drug effects ; pig ; Polo-Like Kinase 1 ; Protein Kinase Inhibitors - pharmacology ; Protein Serine-Threonine Kinases - antagonists & inhibitors ; Protein Serine-Threonine Kinases - physiology ; Proto-Oncogene Proteins - antagonists & inhibitors ; Proto-Oncogene Proteins - physiology ; Pteridines - pharmacology ; Purines - pharmacology ; Roscovitine ; swine ; Swine - metabolism</subject><ispartof>Animal science journal, 2015-02, Vol.86 (2), p.138-147</ispartof><rights>2014 Japanese Society of Animal Science</rights><rights>2014 Japanese Society of Animal Science.</rights><rights>Copyright © 2015 Japanese Society of Animal Science</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4908-9d6005db4e6c7b7279a5f26688fd81345b9bc57bfe1c6bcd256ac53155b958353</citedby><cites>FETCH-LOGICAL-c4908-9d6005db4e6c7b7279a5f26688fd81345b9bc57bfe1c6bcd256ac53155b958353</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fasj.12258$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fasj.12258$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27928,27929,45578,45579</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25187116$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sathanawongs, Anucha</creatorcontrib><creatorcontrib>Fujiwara, Katsuyoshi</creatorcontrib><creatorcontrib>Kato, Tsubasa</creatorcontrib><creatorcontrib>Hirose, Masahiko</creatorcontrib><creatorcontrib>Kamoshita, Maki</creatorcontrib><creatorcontrib>Wojcikiewicz, Richard J. H</creatorcontrib><creatorcontrib>Parys, Jan B</creatorcontrib><creatorcontrib>Ito, Junya</creatorcontrib><creatorcontrib>Kashiwazaki, Naomi</creatorcontrib><title>effect of M‐phase stage‐dependent kinase inhibitors on inositol 1,4,5‐trisphosphate receptor 1 (IP3R1) expression and localization in pig oocytes</title><title>Animal science journal</title><addtitle>Animal Science Journal</addtitle><description>At fertilization, inositol 1,4,5‐trisphosphate receptor type 1 (IP₃R1) has a crucial role in Ca²⁺release in mammals. Expression levels, localization and phosphorylation of IP₃R1 are important for its function, but it still remains unclear which molecule(s) regulates IP₃R1 behavior in pig oocytes. We examined whether there was a difference in localization of IP₃R1 after in vitro or in vivo maturation of pig oocytes. In mouse oocytes, large clusters of IP₃R1 were formed in the cortex of the oocyte except in a ring‐shaped band of cortex adjacent to the spindle. However, no such clusters of IP₃R1 were observed in pig oocytes and there was no difference in its localization between in vitro and in vivo matured oocytes. We next tried to clarify which factor(s) regulates IP₃R1 localization, phosphorylation and expression using M‐phase stage‐dependent kinase inhibitors. Our results show that treatments with roscovitine (p34ᶜᵈᶜ²kinase inhibitor) or U0126 (mitogen‐activated protein kinase inhibitor) did not affect IP₃R1 expression or localization in pig oocytes, although the latter strongly inhibited phosphorylation. However, treatment with BI‐2536, an inhibitor of polo‐like kinase 1 (Plk1), dramatically decreased the expression level of IP₃R1 in pig oocytes in a dose‐dependent manner. From these results, it is suggested that Plk1 is involved in the regulation of IP₃R1 expression in pig oocytes.</description><subject>5-trisphosphate receptor</subject><subject>Animals</subject><subject>Butadienes - pharmacology</subject><subject>Calcium - metabolism</subject><subject>Cell Cycle Proteins - antagonists & inhibitors</subject><subject>Cell Cycle Proteins - physiology</subject><subject>Cells, Cultured</subject><subject>cortex</subject><subject>Cyclin-dependent kinases</subject><subject>dose response</subject><subject>Dose-Response Relationship, Drug</subject><subject>Gene Expression - drug effects</subject><subject>Hogs</subject><subject>inositol 1</subject><subject>Inositol 1,4,5-Trisphosphate Receptors - genetics</subject><subject>Inositol 1,4,5-Trisphosphate Receptors - metabolism</subject><subject>Inositol 1,4,5-Trisphosphate Receptors - physiology</subject><subject>inositols</subject><subject>Kinases</subject><subject>maturation</subject><subject>Mice</subject><subject>mitogen-activated protein kinase</subject><subject>Nitriles - pharmacology</subject><subject>oocyte</subject><subject>oocytes</subject><subject>Oocytes - metabolism</subject><subject>Phosphorylation</subject><subject>Phosphorylation - drug effects</subject><subject>pig</subject><subject>Polo-Like Kinase 1</subject><subject>Protein Kinase Inhibitors - pharmacology</subject><subject>Protein Serine-Threonine Kinases - antagonists & inhibitors</subject><subject>Protein Serine-Threonine Kinases - physiology</subject><subject>Proto-Oncogene Proteins - antagonists & inhibitors</subject><subject>Proto-Oncogene Proteins - physiology</subject><subject>Pteridines - pharmacology</subject><subject>Purines - pharmacology</subject><subject>Roscovitine</subject><subject>swine</subject><subject>Swine - metabolism</subject><issn>1344-3941</issn><issn>1740-0929</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc9O3DAQxqOqVaG0h75Aa4lLkQjYSfzviFChoC1UUMrRcpzJrpcQp7ZXsD31EXrr-_EkeAlww5LlGc1vvpHny7KPBO-QdHZ1mO-QoqDiVbZOeIVzLAv5OsVlVeWlrMha9i6EOcaES0zfZmsFJYITwtaz_9C2YCJyLfp-9_ffMNMBUIh6CilrYIC-gT6iK9uvCraf2dpG5wNyfcpcSEmHyHa1TRMfvQ3DzKWrIyAPBobEIoK-HP0oz8gWgtvBQwg2Neu-QZ0zurN_dLQPamiwU-ScWUYI77M3re4CfHh8N7KLg68_97_lk9PDo_29SW4qiUUuG4YxbeoKmOE1L7jUtC0YE6JtRPo-rWVtKK9bIIbVpiko04aWhKYCFSUtN7LNUXfw7vcCQlRzt_B9GqkIqwStOJMyUVsjZbwLwUOrBm-vtV8qgtXKApUsUA8WJPbTo-KivobmmXzaeQJ2R-DGdrB8WUntnR8_SeZjhw0Rbp87tL9SjJecqsuTQzU5Zmcnl7-EWk34PPKtdkpPkyvq4rzAJO2KYMpFUd4DEeCsAg</recordid><startdate>201502</startdate><enddate>201502</enddate><creator>Sathanawongs, Anucha</creator><creator>Fujiwara, Katsuyoshi</creator><creator>Kato, Tsubasa</creator><creator>Hirose, Masahiko</creator><creator>Kamoshita, Maki</creator><creator>Wojcikiewicz, Richard J. H</creator><creator>Parys, Jan B</creator><creator>Ito, Junya</creator><creator>Kashiwazaki, Naomi</creator><general>Japanese Society of Zootechnical Science, Jan. 1999-<Apr. 2003></general><general>Blackwell Publishing Ltd</general><scope>FBQ</scope><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>201502</creationdate><title>effect of M‐phase stage‐dependent kinase inhibitors on inositol 1,4,5‐trisphosphate receptor 1 (IP3R1) expression and localization in pig oocytes</title><author>Sathanawongs, Anucha ; Fujiwara, Katsuyoshi ; Kato, Tsubasa ; Hirose, Masahiko ; Kamoshita, Maki ; Wojcikiewicz, Richard J. H ; Parys, Jan B ; Ito, Junya ; Kashiwazaki, Naomi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4908-9d6005db4e6c7b7279a5f26688fd81345b9bc57bfe1c6bcd256ac53155b958353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>5-trisphosphate receptor</topic><topic>Animals</topic><topic>Butadienes - pharmacology</topic><topic>Calcium - metabolism</topic><topic>Cell Cycle Proteins - antagonists & inhibitors</topic><topic>Cell Cycle Proteins - physiology</topic><topic>Cells, Cultured</topic><topic>cortex</topic><topic>Cyclin-dependent kinases</topic><topic>dose response</topic><topic>Dose-Response Relationship, Drug</topic><topic>Gene Expression - drug effects</topic><topic>Hogs</topic><topic>inositol 1</topic><topic>Inositol 1,4,5-Trisphosphate Receptors - genetics</topic><topic>Inositol 1,4,5-Trisphosphate Receptors - metabolism</topic><topic>Inositol 1,4,5-Trisphosphate Receptors - physiology</topic><topic>inositols</topic><topic>Kinases</topic><topic>maturation</topic><topic>Mice</topic><topic>mitogen-activated protein kinase</topic><topic>Nitriles - pharmacology</topic><topic>oocyte</topic><topic>oocytes</topic><topic>Oocytes - metabolism</topic><topic>Phosphorylation</topic><topic>Phosphorylation - drug effects</topic><topic>pig</topic><topic>Polo-Like Kinase 1</topic><topic>Protein Kinase Inhibitors - pharmacology</topic><topic>Protein Serine-Threonine Kinases - antagonists & inhibitors</topic><topic>Protein Serine-Threonine Kinases - physiology</topic><topic>Proto-Oncogene Proteins - antagonists & inhibitors</topic><topic>Proto-Oncogene Proteins - physiology</topic><topic>Pteridines - pharmacology</topic><topic>Purines - pharmacology</topic><topic>Roscovitine</topic><topic>swine</topic><topic>Swine - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sathanawongs, Anucha</creatorcontrib><creatorcontrib>Fujiwara, Katsuyoshi</creatorcontrib><creatorcontrib>Kato, Tsubasa</creatorcontrib><creatorcontrib>Hirose, Masahiko</creatorcontrib><creatorcontrib>Kamoshita, Maki</creatorcontrib><creatorcontrib>Wojcikiewicz, Richard J. H</creatorcontrib><creatorcontrib>Parys, Jan B</creatorcontrib><creatorcontrib>Ito, Junya</creatorcontrib><creatorcontrib>Kashiwazaki, Naomi</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Animal science journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sathanawongs, Anucha</au><au>Fujiwara, Katsuyoshi</au><au>Kato, Tsubasa</au><au>Hirose, Masahiko</au><au>Kamoshita, Maki</au><au>Wojcikiewicz, Richard J. H</au><au>Parys, Jan B</au><au>Ito, Junya</au><au>Kashiwazaki, Naomi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>effect of M‐phase stage‐dependent kinase inhibitors on inositol 1,4,5‐trisphosphate receptor 1 (IP3R1) expression and localization in pig oocytes</atitle><jtitle>Animal science journal</jtitle><addtitle>Animal Science Journal</addtitle><date>2015-02</date><risdate>2015</risdate><volume>86</volume><issue>2</issue><spage>138</spage><epage>147</epage><pages>138-147</pages><issn>1344-3941</issn><eissn>1740-0929</eissn><abstract>At fertilization, inositol 1,4,5‐trisphosphate receptor type 1 (IP₃R1) has a crucial role in Ca²⁺release in mammals. Expression levels, localization and phosphorylation of IP₃R1 are important for its function, but it still remains unclear which molecule(s) regulates IP₃R1 behavior in pig oocytes. We examined whether there was a difference in localization of IP₃R1 after in vitro or in vivo maturation of pig oocytes. In mouse oocytes, large clusters of IP₃R1 were formed in the cortex of the oocyte except in a ring‐shaped band of cortex adjacent to the spindle. However, no such clusters of IP₃R1 were observed in pig oocytes and there was no difference in its localization between in vitro and in vivo matured oocytes. We next tried to clarify which factor(s) regulates IP₃R1 localization, phosphorylation and expression using M‐phase stage‐dependent kinase inhibitors. Our results show that treatments with roscovitine (p34ᶜᵈᶜ²kinase inhibitor) or U0126 (mitogen‐activated protein kinase inhibitor) did not affect IP₃R1 expression or localization in pig oocytes, although the latter strongly inhibited phosphorylation. However, treatment with BI‐2536, an inhibitor of polo‐like kinase 1 (Plk1), dramatically decreased the expression level of IP₃R1 in pig oocytes in a dose‐dependent manner. From these results, it is suggested that Plk1 is involved in the regulation of IP₃R1 expression in pig oocytes.</abstract><cop>Australia</cop><pub>Japanese Society of Zootechnical Science, Jan. 1999-<Apr. 2003></pub><pmid>25187116</pmid><doi>10.1111/asj.12258</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1344-3941 |
| ispartof | Animal science journal, 2015-02, Vol.86 (2), p.138-147 |
| issn | 1344-3941 1740-0929 |
| language | eng |
| recordid | cdi_proquest_journals_1648547699 |
| source | MEDLINE; Access via Wiley Online Library; Alma/SFX Local Collection |
| subjects | 5-trisphosphate receptor Animals Butadienes - pharmacology Calcium - metabolism Cell Cycle Proteins - antagonists & inhibitors Cell Cycle Proteins - physiology Cells, Cultured cortex Cyclin-dependent kinases dose response Dose-Response Relationship, Drug Gene Expression - drug effects Hogs inositol 1 Inositol 1,4,5-Trisphosphate Receptors - genetics Inositol 1,4,5-Trisphosphate Receptors - metabolism Inositol 1,4,5-Trisphosphate Receptors - physiology inositols Kinases maturation Mice mitogen-activated protein kinase Nitriles - pharmacology oocyte oocytes Oocytes - metabolism Phosphorylation Phosphorylation - drug effects pig Polo-Like Kinase 1 Protein Kinase Inhibitors - pharmacology Protein Serine-Threonine Kinases - antagonists & inhibitors Protein Serine-Threonine Kinases - physiology Proto-Oncogene Proteins - antagonists & inhibitors Proto-Oncogene Proteins - physiology Pteridines - pharmacology Purines - pharmacology Roscovitine swine Swine - metabolism |
| title | effect of M‐phase stage‐dependent kinase inhibitors on inositol 1,4,5‐trisphosphate receptor 1 (IP3R1) expression and localization in pig oocytes |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-17T13%3A01%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=effect%20of%20M%E2%80%90phase%20stage%E2%80%90dependent%20kinase%20inhibitors%20on%20inositol%201,4,5%E2%80%90trisphosphate%20receptor%201%20(IP3R1)%20expression%20and%20localization%20in%20pig%20oocytes&rft.jtitle=Animal%20science%20journal&rft.au=Sathanawongs,%20Anucha&rft.date=2015-02&rft.volume=86&rft.issue=2&rft.spage=138&rft.epage=147&rft.pages=138-147&rft.issn=1344-3941&rft.eissn=1740-0929&rft_id=info:doi/10.1111/asj.12258&rft_dat=%3Cproquest_cross%3E3570867091%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1648547699&rft_id=info:pmid/25187116&rfr_iscdi=true |