miR-7-5p suppresses cell proliferation and induces apoptosis of breast cancer cells mainly by targeting REG[gamma]
Proteasome activator subunit 3 (REGγ) has a key role in breast cancer by promoting protein proteolysis, but methods to block REGγ expression remain elusive. In this study, we found that the expression of REGγ is significantly upregulated in breast cancer, and that the knockdown of REGγ expression su...
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| Veröffentlicht in: | Cancer letters 2015-03, Vol.358 (1), p.27 |
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| container_issue | 1 |
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| container_title | Cancer letters |
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| creator | Shi, Yuan Luo, Xinrong Li, Peng Tan, Jinxiang Wang, Xiaoyi Xiang, Tingxiu Ren, Guosheng |
| description | Proteasome activator subunit 3 (REGγ) has a key role in breast cancer by promoting protein proteolysis, but methods to block REGγ expression remain elusive. In this study, we found that the expression of REGγ is significantly upregulated in breast cancer, and that the knockdown of REGγ expression suppresses cell proliferation and induces apoptosisin vitro. Furthermore, REGγ was identified as a direct downstream target of miR-7-5p, and there was an inverse correlation between the expression of REGγ and miR-7-5p. The overexpression of miR-7-5p inhibited cell proliferation and induced apoptosis by mainly targeting REGγin vitroandin vivo. Our data indicate that miR-7-5p has a critical function through blocking REGγ in breast cancer cells. |
| doi_str_mv | 10.1016/j.canlet.2014.12.014 |
| format | Article |
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In this study, we found that the expression of REGγ is significantly upregulated in breast cancer, and that the knockdown of REGγ expression suppresses cell proliferation and induces apoptosisin vitro. Furthermore, REGγ was identified as a direct downstream target of miR-7-5p, and there was an inverse correlation between the expression of REGγ and miR-7-5p. The overexpression of miR-7-5p inhibited cell proliferation and induced apoptosis by mainly targeting REGγin vitroandin vivo. 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| ispartof | Cancer letters, 2015-03, Vol.358 (1), p.27 |
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| subjects | Breast cancer Cell cycle Genes Kinases |
| title | miR-7-5p suppresses cell proliferation and induces apoptosis of breast cancer cells mainly by targeting REG[gamma] |
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