Novel Synthesis of Some Imidazolyl-, Benzoxazinyl-, and Quinazolinyl-2,4-dioxothiazolidine Derivatives
2‐(2,4‐Dioxothiazolidin‐5‐yl)acetic acid 1 and its chloride derivative 2 were allowed to react with different aromatic amines such as o‐phenylenediamine, o‐aminothiophenol, p‐aminoacetophenone, and anthranilic acid to give the biologically active nuclei such as imidazoles, thiazoles, benzoxazines, a...
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| Veröffentlicht in: | Journal of heterocyclic chemistry 2015-01, Vol.52 (1), p.278-283 |
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| container_end_page | 283 |
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| container_title | Journal of heterocyclic chemistry |
| container_volume | 52 |
| creator | Youssef, Ali M. EL-Ziaty, Ahmed K. Abou-Elmagd, Wael S. I. Ramadan, Sayed K. |
| description | 2‐(2,4‐Dioxothiazolidin‐5‐yl)acetic acid 1 and its chloride derivative 2 were allowed to react with different aromatic amines such as o‐phenylenediamine, o‐aminothiophenol, p‐aminoacetophenone, and anthranilic acid to give the biologically active nuclei such as imidazoles, thiazoles, benzoxazines, and quinazolines incorporated with the thiazolidindione nucleus. The antimicrobial activity of five of the synthesized compounds was examined against one gram positive bacteria (Staphylococcus aureus), one gram negative bacteria (Escherichia coli), and two fungi (Aspergillus flavus and Candida albicans). Four compounds showed moderate antibacterial and antifungal activities. |
| doi_str_mv | 10.1002/jhet.1943 |
| format | Article |
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| language | eng |
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| subjects | Gram-positive bacteria |
| title | Novel Synthesis of Some Imidazolyl-, Benzoxazinyl-, and Quinazolinyl-2,4-dioxothiazolidine Derivatives |
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