Prevention of Nephrotoxicity Induced by Cyclosporine-A: Role of Antioxidants

ABSTRACT Cyclosporine A (CsA) is a powerful immunosuppressive drug used to prevent allograft rejection after organ transplantation as well as in human and veterinary medicine. Unfortunately, its use is hampered by its nephrotoxic effects. The mechanisms of CsA‐induced hypertension and nephrotoxicity...

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Veröffentlicht in:	Journal of cellular biochemistry 2015-03, Vol.116 (3), p.364-369
Hauptverfasser:	Damiano, Sara, Ciarcia, Roberto, Montagnaro, Serena, Pagnini, Ugo, Garofano, Tiziana, Capasso, Giovambattista, Florio, Salvatore, Giordano, Antonio
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals ANTIOXIDANT Antioxidants - therapeutic use Cyclosporine - adverse effects CYCLOSPORINE-A (CsA) Humans Kidney Diseases - chemically induced Kidney Diseases - prevention & control NEPHROTOXICITY Oxidative Stress - drug effects REACTING OXYGEN SPECIES (ROS)
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