Prevention of Nephrotoxicity Induced by Cyclosporine-A: Role of Antioxidants
ABSTRACT Cyclosporine A (CsA) is a powerful immunosuppressive drug used to prevent allograft rejection after organ transplantation as well as in human and veterinary medicine. Unfortunately, its use is hampered by its nephrotoxic effects. The mechanisms of CsA‐induced hypertension and nephrotoxicity...
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| Veröffentlicht in: | Journal of cellular biochemistry 2015-03, Vol.116 (3), p.364-369 |
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| container_title | Journal of cellular biochemistry |
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| creator | Damiano, Sara Ciarcia, Roberto Montagnaro, Serena Pagnini, Ugo Garofano, Tiziana Capasso, Giovambattista Florio, Salvatore Giordano, Antonio |
| description | ABSTRACT
Cyclosporine A (CsA) is a powerful immunosuppressive drug used to prevent allograft rejection after organ transplantation as well as in human and veterinary medicine. Unfortunately, its use is hampered by its nephrotoxic effects. The mechanisms of CsA‐induced hypertension and nephrotoxicity are not clear, but several studies suggest the possible involvement of free radicals. In this review we have summarized the effect of some antioxidants that we have used in the recent years, in combination with CsA, to better understand the exact mechanism of action of CsA and to try to open new perspectives in the treatment of CsA nephrotoxicity. J. Cell. Biochem. 116: 364–369, 2015. © 2014 Wiley Periodicals, Inc. |
| doi_str_mv | 10.1002/jcb.25022 |
| format | Article |
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Cyclosporine A (CsA) is a powerful immunosuppressive drug used to prevent allograft rejection after organ transplantation as well as in human and veterinary medicine. Unfortunately, its use is hampered by its nephrotoxic effects. The mechanisms of CsA‐induced hypertension and nephrotoxicity are not clear, but several studies suggest the possible involvement of free radicals. In this review we have summarized the effect of some antioxidants that we have used in the recent years, in combination with CsA, to better understand the exact mechanism of action of CsA and to try to open new perspectives in the treatment of CsA nephrotoxicity. J. Cell. Biochem. 116: 364–369, 2015. © 2014 Wiley Periodicals, Inc.</description><identifier>ISSN: 0730-2312</identifier><identifier>EISSN: 1097-4644</identifier><identifier>DOI: 10.1002/jcb.25022</identifier><identifier>PMID: 25418335</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Animals ; ANTIOXIDANT ; Antioxidants - therapeutic use ; Cyclosporine - adverse effects ; CYCLOSPORINE-A (CsA) ; Humans ; Kidney Diseases - chemically induced ; Kidney Diseases - prevention & control ; NEPHROTOXICITY ; Oxidative Stress - drug effects ; REACTING OXYGEN SPECIES (ROS)</subject><ispartof>Journal of cellular biochemistry, 2015-03, Vol.116 (3), p.364-369</ispartof><rights>2014 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5272-24b344ff34bbd0fdafec1d01685320846c304a15a00f7348266fe1d9d903dfe03</citedby><cites>FETCH-LOGICAL-c5272-24b344ff34bbd0fdafec1d01685320846c304a15a00f7348266fe1d9d903dfe03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjcb.25022$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjcb.25022$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25418335$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Damiano, Sara</creatorcontrib><creatorcontrib>Ciarcia, Roberto</creatorcontrib><creatorcontrib>Montagnaro, Serena</creatorcontrib><creatorcontrib>Pagnini, Ugo</creatorcontrib><creatorcontrib>Garofano, Tiziana</creatorcontrib><creatorcontrib>Capasso, Giovambattista</creatorcontrib><creatorcontrib>Florio, Salvatore</creatorcontrib><creatorcontrib>Giordano, Antonio</creatorcontrib><title>Prevention of Nephrotoxicity Induced by Cyclosporine-A: Role of Antioxidants</title><title>Journal of cellular biochemistry</title><addtitle>J. Cell. Biochem</addtitle><description>ABSTRACT
Cyclosporine A (CsA) is a powerful immunosuppressive drug used to prevent allograft rejection after organ transplantation as well as in human and veterinary medicine. Unfortunately, its use is hampered by its nephrotoxic effects. The mechanisms of CsA‐induced hypertension and nephrotoxicity are not clear, but several studies suggest the possible involvement of free radicals. In this review we have summarized the effect of some antioxidants that we have used in the recent years, in combination with CsA, to better understand the exact mechanism of action of CsA and to try to open new perspectives in the treatment of CsA nephrotoxicity. J. Cell. Biochem. 116: 364–369, 2015. © 2014 Wiley Periodicals, Inc.</description><subject>Animals</subject><subject>ANTIOXIDANT</subject><subject>Antioxidants - therapeutic use</subject><subject>Cyclosporine - adverse effects</subject><subject>CYCLOSPORINE-A (CsA)</subject><subject>Humans</subject><subject>Kidney Diseases - chemically induced</subject><subject>Kidney Diseases - prevention & control</subject><subject>NEPHROTOXICITY</subject><subject>Oxidative Stress - drug effects</subject><subject>REACTING OXYGEN SPECIES (ROS)</subject><issn>0730-2312</issn><issn>1097-4644</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEtPwkAURidGI4gu_AOmiSsXhTvPtu6QKGIIEuNjOWk7M7EIHZwpSv-9RYSdq7s537nJQegcQxcDkN4sz7qEAyEHqI0hiUImGDtEbYgohIRi0kIn3s8AIEkoOUYtwhmOKeVtNJ46_aXLqrBlYE0w0ct3Zyu7LvKiqoNRqVa5VkFWB4M6n1u_tK4oddi_Dp7sXG8W_c12Xai0rPwpOjLp3Ouzv9tBL3e3z4P7cPw4HA364zDnJCIhYRllzBjKskyBUanROVaARcwpgZiJnAJLMU8BTERZTIQwGqtEJUCV0UA76HLrXTr7udK-kjO7cmXzUmLBGo3gsWioqy2VO-u900YuXbFIXS0xyE032XSTv90a9uLPuMoWWu3JXagG6G2B72Ku6_9N8mFws1OG20XhK73eL1L3IUVEIy7fJkP5GhE2nXAhGf0BwxOEqg</recordid><startdate>201503</startdate><enddate>201503</enddate><creator>Damiano, Sara</creator><creator>Ciarcia, Roberto</creator><creator>Montagnaro, Serena</creator><creator>Pagnini, Ugo</creator><creator>Garofano, Tiziana</creator><creator>Capasso, Giovambattista</creator><creator>Florio, Salvatore</creator><creator>Giordano, Antonio</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope></search><sort><creationdate>201503</creationdate><title>Prevention of Nephrotoxicity Induced by Cyclosporine-A: Role of Antioxidants</title><author>Damiano, Sara ; Ciarcia, Roberto ; Montagnaro, Serena ; Pagnini, Ugo ; Garofano, Tiziana ; Capasso, Giovambattista ; Florio, Salvatore ; Giordano, Antonio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5272-24b344ff34bbd0fdafec1d01685320846c304a15a00f7348266fe1d9d903dfe03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>ANTIOXIDANT</topic><topic>Antioxidants - therapeutic use</topic><topic>Cyclosporine - adverse effects</topic><topic>CYCLOSPORINE-A (CsA)</topic><topic>Humans</topic><topic>Kidney Diseases - chemically induced</topic><topic>Kidney Diseases - prevention & control</topic><topic>NEPHROTOXICITY</topic><topic>Oxidative Stress - drug effects</topic><topic>REACTING OXYGEN SPECIES (ROS)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Damiano, Sara</creatorcontrib><creatorcontrib>Ciarcia, Roberto</creatorcontrib><creatorcontrib>Montagnaro, Serena</creatorcontrib><creatorcontrib>Pagnini, Ugo</creatorcontrib><creatorcontrib>Garofano, Tiziana</creatorcontrib><creatorcontrib>Capasso, Giovambattista</creatorcontrib><creatorcontrib>Florio, Salvatore</creatorcontrib><creatorcontrib>Giordano, Antonio</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Journal of cellular biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Damiano, Sara</au><au>Ciarcia, Roberto</au><au>Montagnaro, Serena</au><au>Pagnini, Ugo</au><au>Garofano, Tiziana</au><au>Capasso, Giovambattista</au><au>Florio, Salvatore</au><au>Giordano, Antonio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevention of Nephrotoxicity Induced by Cyclosporine-A: Role of Antioxidants</atitle><jtitle>Journal of cellular biochemistry</jtitle><addtitle>J. Cell. Biochem</addtitle><date>2015-03</date><risdate>2015</risdate><volume>116</volume><issue>3</issue><spage>364</spage><epage>369</epage><pages>364-369</pages><issn>0730-2312</issn><eissn>1097-4644</eissn><abstract>ABSTRACT
Cyclosporine A (CsA) is a powerful immunosuppressive drug used to prevent allograft rejection after organ transplantation as well as in human and veterinary medicine. Unfortunately, its use is hampered by its nephrotoxic effects. The mechanisms of CsA‐induced hypertension and nephrotoxicity are not clear, but several studies suggest the possible involvement of free radicals. In this review we have summarized the effect of some antioxidants that we have used in the recent years, in combination with CsA, to better understand the exact mechanism of action of CsA and to try to open new perspectives in the treatment of CsA nephrotoxicity. J. Cell. Biochem. 116: 364–369, 2015. © 2014 Wiley Periodicals, Inc.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>25418335</pmid><doi>10.1002/jcb.25022</doi><tpages>6</tpages></addata></record> |
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| subjects | Animals ANTIOXIDANT Antioxidants - therapeutic use Cyclosporine - adverse effects CYCLOSPORINE-A (CsA) Humans Kidney Diseases - chemically induced Kidney Diseases - prevention & control NEPHROTOXICITY Oxidative Stress - drug effects REACTING OXYGEN SPECIES (ROS) |
| title | Prevention of Nephrotoxicity Induced by Cyclosporine-A: Role of Antioxidants |
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