Autophagy may occur at an early stage of cholangiocarcinogenesis via biliary intraepithelial neoplasia

Summary Similar to the pancreatic carcinoma sequence model, cholangiocarcinoma reportedly follows a stepwise carcinogenesis process via the precursor lesion biliary intraepithelial neoplasia (BilIN). Given that autophagy plays an important role in the occurrence and development of carcinomas, we exa...

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Veröffentlicht in:	Human pathology 2015-02, Vol.46 (2), p.202-209
Hauptverfasser:	Sasaki, Motoko, MD, PhD, Nitta, Takeo, MD, PhD, Sato, Yasunori, MD, PhD, Nakanuma, Yasuni, MD, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Regulatory Proteins - metabolism Autophagy Autophagy - genetics Autophagy - physiology Beclin-1 Bile Bile Duct Neoplasms - diagnosis Bile Duct Neoplasms - metabolism Bile Duct Neoplasms - pathology Bile Ducts, Intrahepatic - metabolism Bile Ducts, Intrahepatic - pathology Biliary intraepithelial neoplasia (BilIN) Cholangiocarcinoma - diagnosis Cholangiocarcinoma - metabolism Cholangiocarcinoma - pathology Humans Immunohistochemistry - methods Intrahepatic cholangiocarcinoma KRAS Liver Liver - metabolism Membrane Proteins - metabolism Microtubule-Associated Proteins - metabolism Microtubule-associated proteins light chain 3 beta (LC3) Mortality Mutation Neoplasm Staging p62/sequestosome-1 Pathology Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins p21(ras) ras Proteins - metabolism RNA-Binding Proteins - metabolism Rodents
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