Low-Dose Colchicine for Secondary Prevention of Cardiovascular Disease

Objectives The objective of this study was to determine whether colchicine 0.5 mg/day can reduce the risk of cardiovascular events in patients with clinically stable coronary disease. Background The presence of activated neutrophils in culprit atherosclerotic plaques of patients with unstable corona...

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Veröffentlicht in:	Journal of the American College of Cardiology 2013-01, Vol.61 (4), p.404-410
Hauptverfasser:	Nidorf, Stefan M., MD, MBBS, Eikelboom, John W., MBBS, Budgeon, Charley A., BSc (Hons), Thompson, Peter L., MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Coronary Syndrome - epidemiology Acute Coronary Syndrome - etiology Acute Coronary Syndrome - prevention & control Acute coronary syndromes Aged Arteriosclerosis Aspirin Atherosclerosis Biological and medical sciences Brain Infarction - epidemiology Brain Infarction - etiology Brain Infarction - prevention & control Canada - epidemiology Cardiology Cardiology. Vascular system Cardiovascular Cardiovascular diseases Clopidogrel Colchicine Colchicine - administration & dosage Colchicine - adverse effects Confidence intervals Consent Coronary Disease - complications Coronary Disease - drug therapy Coronary Disease - physiopathology Disease prevention Drug dosages Drug Therapy, Combination Endpoint Determination Female Health risks Heart attacks Heart surgery Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage Incidence Internal Medicine Intestinal Diseases - chemically induced Intestine Intolerance Ischemia Leukocytes (neutrophilic) Male Medical sciences Motivation Out-of-Hospital Cardiac Arrest - epidemiology Out-of-Hospital Cardiac Arrest - etiology Out-of-Hospital Cardiac Arrest - prevention & control Patients Plaque, Atherosclerotic - drug therapy Plaque, Atherosclerotic - etiology Plaque, Atherosclerotic - physiopathology Plaques Prevention Proportional Hazards Models Risk Assessment secondary prevention Secondary Prevention - methods Stability stable coronary disease Statins Stroke Treatment Outcome Tubulin Modulators - administration & dosage Tubulin Modulators - adverse effects Withholding Treatment - statistics & numerical data
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