Identification of multipotent mammary stemcells by protein C receptor expression
The mammary gland is composed of multiple types of epithelial cells, which are generated by mammary stem cells (MaSCs) residing at the top of the hierarchy1,2. However, the existence of these multi-potent MaSCs remains controversial and the nature of such cells is unknown3,4. Here we demonstrate tha...
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| Veröffentlicht in: | Nature (London) 2015-01, Vol.517 (7532), p.81 |
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| creator | Wang, Daisong Cai, Cheguo Dong, Xiaobing Yu, Qing Cissy Zhang, Xiao-Ou Yang, Li Zeng, Yi Arial |
| description | The mammary gland is composed of multiple types of epithelial cells, which are generated by mammary stem cells (MaSCs) residing at the top of the hierarchy1,2. However, the existence of these multi-potent MaSCs remains controversial and the nature of such cells is unknown3,4. Here we demonstrate that protein C receptor (Procr), a novel Wnt target in the mammary gland, marks a unique population of multipotent mouse MaSCs. Procr-positive cells localize to the basal layer, exhibit epithelial-to-mesenchymal transition characteristics, and express low levels of basal keratins. Procr-expressing cells have a high regenerative capacity in transplantation assays and differentiate into all lineages of the mammary epithelium by lineage tracing. These results define a novel multipotent mammary stem cell population that could be important in the initiation of breast cancer. |
| doi_str_mv | 10.1038/nature13851 |
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However, the existence of these multi-potent MaSCs remains controversial and the nature of such cells is unknown3,4. Here we demonstrate that protein C receptor (Procr), a novel Wnt target in the mammary gland, marks a unique population of multipotent mouse MaSCs. Procr-positive cells localize to the basal layer, exhibit epithelial-to-mesenchymal transition characteristics, and express low levels of basal keratins. Procr-expressing cells have a high regenerative capacity in transplantation assays and differentiate into all lineages of the mammary epithelium by lineage tracing. These results define a novel multipotent mammary stem cell population that could be important in the initiation of breast cancer.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/nature13851</identifier><identifier>CODEN: NATUAS</identifier><language>eng</language><publisher>London: Nature Publishing Group</publisher><subject>Breast cancer ; Breasts ; Proteins ; Rodents ; Stem cells ; Studies</subject><ispartof>Nature (London), 2015-01, Vol.517 (7532), p.81</ispartof><rights>Copyright Nature Publishing Group Jan 1, 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>Wang, Daisong</creatorcontrib><creatorcontrib>Cai, Cheguo</creatorcontrib><creatorcontrib>Dong, Xiaobing</creatorcontrib><creatorcontrib>Yu, Qing Cissy</creatorcontrib><creatorcontrib>Zhang, Xiao-Ou</creatorcontrib><creatorcontrib>Yang, Li</creatorcontrib><creatorcontrib>Zeng, Yi Arial</creatorcontrib><title>Identification of multipotent mammary stemcells by protein C receptor expression</title><title>Nature (London)</title><description>The mammary gland is composed of multiple types of epithelial cells, which are generated by mammary stem cells (MaSCs) residing at the top of the hierarchy1,2. 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| subjects | Breast cancer Breasts Proteins Rodents Stem cells Studies |
| title | Identification of multipotent mammary stemcells by protein C receptor expression |
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