Protein-bound polysaccharide decreases invasiveness and proliferation in pancreatic cancer by inhibition of hedgehog signaling and HIF-1[alpha] pathways under hypoxia

Protein-bound polysaccharide decreases invasiveness and proliferation in pancreatic cancer by inhibition of hedgehog signaling and HIF-1[alpha] pathways under hypoxia

Highlights * PSK decreased proliferation and invasiveness in pancreatic ductal adenocarcinoma (PDAC) cells under hypoxia. * Decreased proliferation and invasiveness by PSK is due to the inhibition of Hedgehog signaling and HIF-1α pathways. * PSK is a promising therapeutic drug for refractory PDAC.

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Cancer letters 2013-07, Vol.335 (2), p.289
Hauptverfasser: Onishi, Hideya, Morisaki, Takafumi, Nakao, Fumihiko, Odate, Seiichi, Morisaki, Takashi, Katano, Mitsuo
Format: Artikel
Sprache:eng
Schlagworte:
Apoptosis
Cell cycle
Hypoxia
Kinases
Molecular weight
Pancreatic cancer
Proteins
Software
Studies
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Highlights * PSK decreased proliferation and invasiveness in pancreatic ductal adenocarcinoma (PDAC) cells under hypoxia. * Decreased proliferation and invasiveness by PSK is due to the inhibition of Hedgehog signaling and HIF-1α pathways. * PSK is a promising therapeutic drug for refractory PDAC.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2013.02.041