Double-Stranded RNA of Intestinal Commensal but Not Pathogenic Bacteria Triggers Production of Protective Interferon-[beta]
The small intestine harbors a substantial number of commensal bacteria and is sporadically invaded by pathogens, but the response to these microorganisms is fundamentally different. We identified a discriminatory sensor by using Toll-like receptor 3 (TLR3). Double-stranded RNA (dsRNA) of one major c...
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| Veröffentlicht in: | Immunity (Cambridge, Mass.) Mass.), 2013-06, Vol.38 (6), p.1187 |
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| creator | Kawashima, Tadaomi Kosaka, Akemi Yan, Huimin Guo, Zijin Uchiyama, Ryosuke Fukui, Ryutaro Kaneko, Daisuke Kumagai, Yutaro You, Dong-Ju Carreras, Joaquim Uematsu, Satoshi Jang, Myoung Ho Takeuchi, Osamu Kaisho, Tsuneyasu Akira, Shizuo Miyake, Kensuke Tsutsui, Hiroko Saito, Takashi Nishimura, Ikuko Tsuji, Noriko M |
| description | The small intestine harbors a substantial number of commensal bacteria and is sporadically invaded by pathogens, but the response to these microorganisms is fundamentally different. We identified a discriminatory sensor by using Toll-like receptor 3 (TLR3). Double-stranded RNA (dsRNA) of one major commensal species, lactic acid bacteria (LAB), triggered interferon-β (IFN-β) production, which protected mice from experimental colitis. The LAB-induced IFN-β response was diminished by dsRNA digestion and treatment with endosomal inhibitors. Pathogenic bacteria contained less dsRNA and induced much less IFN-β than LAB, and dsRNA was not involved in pathogen-induced IFN-β induction. These results identify TLR3 as a sensor to small intestinal commensal bacteria and suggest that dsRNA in commensal bacteria contributes to anti-inflammatory and protective immune responses. |
| doi_str_mv | 10.1016/j.immuni.2013.02.024 |
| format | Article |
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| subjects | Bacteria Colon Immune system Infections Inflammatory bowel disease Rodents Viral infections |
| title | Double-Stranded RNA of Intestinal Commensal but Not Pathogenic Bacteria Triggers Production of Protective Interferon-[beta] |
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