A Physiologically Based Pharmacokinetic Model for Voriconazole Disposition Predicts Intestinal First-pass Metabolism in Children

Background and Objectives The effect of ontogeny in drug-metabolizing enzymes on pediatric pharmacokinetics is poorly predicted. Voriconazole, a potent antifungal, is cleared predominantly via oxidative metabolism and exhibits vastly different pharmacokinetics between adults and children. A physiolo...

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Veröffentlicht in:	Clinical pharmacokinetics 2014-12, Vol.53 (12), p.1171-1182
Hauptverfasser:	Zane, Nicole R., Thakker, Dhiren R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal agents Antifungal Agents - blood Antifungal Agents - pharmacokinetics Biological and medical sciences Biological Availability Child Child, Preschool Female Healthy Volunteers Humans Internal Medicine Intestines - metabolism Male Medical sciences Medicine Medicine & Public Health Models, Biological Original Research Article Pharmacology. Drug treatments Pharmacology/Toxicology Pharmacotherapy Reproducibility of Results Voriconazole - blood Voriconazole - pharmacokinetics
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