Cdkn2a/p16^sup Ink4a^ Regulates Fasting-Induced Hepatic Gluconeogenesis Through the PKA-CREB-PGC1[alpha] Pathway
Type 2 diabetes (T2D) is hallmarked by insulin resistance, impaired insulin secretion, and increased hepatic glucose production. The worldwide increasing prevalence of T2D calls for efforts to understand its pathogenesis in order to improve disease prevention and management. Recent genome-wide assoc...
Gespeichert in:
| Veröffentlicht in: | Diabetes (New York, N.Y.) N.Y.), 2014-10, Vol.63 (10), p.3199 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 10 |
| container_start_page | 3199 |
| container_title | Diabetes (New York, N.Y.) |
| container_volume | 63 |
| creator | Bantubungi, Kadiombo Hannou, Sarah-Anissa Caron-Houde, Sandrine Vallez, Emmanuelle Baron, Morgane Lucas, Anthony Bouchaert, Emmanuel Paumelle, Réjane Tailleux, Anne Staels, Bart |
| description | Type 2 diabetes (T2D) is hallmarked by insulin resistance, impaired insulin secretion, and increased hepatic glucose production. The worldwide increasing prevalence of T2D calls for efforts to understand its pathogenesis in order to improve disease prevention and management. Recent genome-wide association studies have revealed strong associations between the CDKN2A/B locus and T2D risk. The CDKN2A/B locus contains genes encoding cell cycle inhibitors, including p16..., which have not yet been implicated in the control of hepatic glucose homeostasis. Here, we show that p16... deficiency enhances fasting-induced hepatic glucose production in vivo by increasing the expression of key gluconeogenic genes. p16... downregulation leads to an activation of PKA-CREB-PGC1α signaling through increased phosphorylation of PKA regulatory subunits. Taken together, these results provide evidence that p16... controls fasting glucose homeostasis and could as such be involved in T2D development. (ProQuest: ... denotes formulae/symbols omitted.) |
| format | Article |
| fullrecord | <record><control><sourceid>proquest</sourceid><recordid>TN_cdi_proquest_journals_1638915405</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3533699441</sourcerecordid><originalsourceid>FETCH-proquest_journals_16389154053</originalsourceid><addsrcrecordid>eNqNistqwzAQAEVoIe7jHxZ6FpXsxI6PrcmLXkzIoVCasNgby4mRVK9E6d83h35AmcMcZiYi0WVWyiwt3m9EopROpS7KYirumM9KqfxKInzVXmyKz17nB44etvYywwPsqIsDBmJYIYfednJr29hQCxvyGPoG1kNsnCXXkSXuGfZmdLEzEAxB_fYiq93yVdbrSn_g4A1-Qo3BfOPPg7g94cD0-Od78bRa7quN9KP7isTheHZxtNd01Hm2KPV8pubZ_65f60RKEg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1638915405</pqid></control><display><type>article</type><title>Cdkn2a/p16^sup Ink4a^ Regulates Fasting-Induced Hepatic Gluconeogenesis Through the PKA-CREB-PGC1[alpha] Pathway</title><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Journals@Ovid Ovid Autoload</source><source>PubMed Central</source><creator>Bantubungi, Kadiombo ; Hannou, Sarah-Anissa ; Caron-Houde, Sandrine ; Vallez, Emmanuelle ; Baron, Morgane ; Lucas, Anthony ; Bouchaert, Emmanuel ; Paumelle, Réjane ; Tailleux, Anne ; Staels, Bart</creator><creatorcontrib>Bantubungi, Kadiombo ; Hannou, Sarah-Anissa ; Caron-Houde, Sandrine ; Vallez, Emmanuelle ; Baron, Morgane ; Lucas, Anthony ; Bouchaert, Emmanuel ; Paumelle, Réjane ; Tailleux, Anne ; Staels, Bart</creatorcontrib><description>Type 2 diabetes (T2D) is hallmarked by insulin resistance, impaired insulin secretion, and increased hepatic glucose production. The worldwide increasing prevalence of T2D calls for efforts to understand its pathogenesis in order to improve disease prevention and management. Recent genome-wide association studies have revealed strong associations between the CDKN2A/B locus and T2D risk. The CDKN2A/B locus contains genes encoding cell cycle inhibitors, including p16..., which have not yet been implicated in the control of hepatic glucose homeostasis. Here, we show that p16... deficiency enhances fasting-induced hepatic glucose production in vivo by increasing the expression of key gluconeogenic genes. p16... downregulation leads to an activation of PKA-CREB-PGC1α signaling through increased phosphorylation of PKA regulatory subunits. Taken together, these results provide evidence that p16... controls fasting glucose homeostasis and could as such be involved in T2D development. (ProQuest: ... denotes formulae/symbols omitted.)</description><identifier>ISSN: 0012-1797</identifier><identifier>EISSN: 1939-327X</identifier><identifier>CODEN: DIAEAZ</identifier><language>eng</language><publisher>New York: American Diabetes Association</publisher><subject>Diabetes ; Fasting ; Genomics ; Glucose ; Homeostasis ; Liver ; Phosphorylation</subject><ispartof>Diabetes (New York, N.Y.), 2014-10, Vol.63 (10), p.3199</ispartof><rights>Copyright American Diabetes Association Oct 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785</link.rule.ids></links><search><creatorcontrib>Bantubungi, Kadiombo</creatorcontrib><creatorcontrib>Hannou, Sarah-Anissa</creatorcontrib><creatorcontrib>Caron-Houde, Sandrine</creatorcontrib><creatorcontrib>Vallez, Emmanuelle</creatorcontrib><creatorcontrib>Baron, Morgane</creatorcontrib><creatorcontrib>Lucas, Anthony</creatorcontrib><creatorcontrib>Bouchaert, Emmanuel</creatorcontrib><creatorcontrib>Paumelle, Réjane</creatorcontrib><creatorcontrib>Tailleux, Anne</creatorcontrib><creatorcontrib>Staels, Bart</creatorcontrib><title>Cdkn2a/p16^sup Ink4a^ Regulates Fasting-Induced Hepatic Gluconeogenesis Through the PKA-CREB-PGC1[alpha] Pathway</title><title>Diabetes (New York, N.Y.)</title><description>Type 2 diabetes (T2D) is hallmarked by insulin resistance, impaired insulin secretion, and increased hepatic glucose production. The worldwide increasing prevalence of T2D calls for efforts to understand its pathogenesis in order to improve disease prevention and management. Recent genome-wide association studies have revealed strong associations between the CDKN2A/B locus and T2D risk. The CDKN2A/B locus contains genes encoding cell cycle inhibitors, including p16..., which have not yet been implicated in the control of hepatic glucose homeostasis. Here, we show that p16... deficiency enhances fasting-induced hepatic glucose production in vivo by increasing the expression of key gluconeogenic genes. p16... downregulation leads to an activation of PKA-CREB-PGC1α signaling through increased phosphorylation of PKA regulatory subunits. Taken together, these results provide evidence that p16... controls fasting glucose homeostasis and could as such be involved in T2D development. (ProQuest: ... denotes formulae/symbols omitted.)</description><subject>Diabetes</subject><subject>Fasting</subject><subject>Genomics</subject><subject>Glucose</subject><subject>Homeostasis</subject><subject>Liver</subject><subject>Phosphorylation</subject><issn>0012-1797</issn><issn>1939-327X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNqNistqwzAQAEVoIe7jHxZ6FpXsxI6PrcmLXkzIoVCasNgby4mRVK9E6d83h35AmcMcZiYi0WVWyiwt3m9EopROpS7KYirumM9KqfxKInzVXmyKz17nB44etvYywwPsqIsDBmJYIYfednJr29hQCxvyGPoG1kNsnCXXkSXuGfZmdLEzEAxB_fYiq93yVdbrSn_g4A1-Qo3BfOPPg7g94cD0-Od78bRa7quN9KP7isTheHZxtNd01Hm2KPV8pubZ_65f60RKEg</recordid><startdate>20141001</startdate><enddate>20141001</enddate><creator>Bantubungi, Kadiombo</creator><creator>Hannou, Sarah-Anissa</creator><creator>Caron-Houde, Sandrine</creator><creator>Vallez, Emmanuelle</creator><creator>Baron, Morgane</creator><creator>Lucas, Anthony</creator><creator>Bouchaert, Emmanuel</creator><creator>Paumelle, Réjane</creator><creator>Tailleux, Anne</creator><creator>Staels, Bart</creator><general>American Diabetes Association</general><scope>K9.</scope><scope>NAPCQ</scope></search><sort><creationdate>20141001</creationdate><title>Cdkn2a/p16^sup Ink4a^ Regulates Fasting-Induced Hepatic Gluconeogenesis Through the PKA-CREB-PGC1[alpha] Pathway</title><author>Bantubungi, Kadiombo ; Hannou, Sarah-Anissa ; Caron-Houde, Sandrine ; Vallez, Emmanuelle ; Baron, Morgane ; Lucas, Anthony ; Bouchaert, Emmanuel ; Paumelle, Réjane ; Tailleux, Anne ; Staels, Bart</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_journals_16389154053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Diabetes</topic><topic>Fasting</topic><topic>Genomics</topic><topic>Glucose</topic><topic>Homeostasis</topic><topic>Liver</topic><topic>Phosphorylation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bantubungi, Kadiombo</creatorcontrib><creatorcontrib>Hannou, Sarah-Anissa</creatorcontrib><creatorcontrib>Caron-Houde, Sandrine</creatorcontrib><creatorcontrib>Vallez, Emmanuelle</creatorcontrib><creatorcontrib>Baron, Morgane</creatorcontrib><creatorcontrib>Lucas, Anthony</creatorcontrib><creatorcontrib>Bouchaert, Emmanuel</creatorcontrib><creatorcontrib>Paumelle, Réjane</creatorcontrib><creatorcontrib>Tailleux, Anne</creatorcontrib><creatorcontrib>Staels, Bart</creatorcontrib><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>Diabetes (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bantubungi, Kadiombo</au><au>Hannou, Sarah-Anissa</au><au>Caron-Houde, Sandrine</au><au>Vallez, Emmanuelle</au><au>Baron, Morgane</au><au>Lucas, Anthony</au><au>Bouchaert, Emmanuel</au><au>Paumelle, Réjane</au><au>Tailleux, Anne</au><au>Staels, Bart</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cdkn2a/p16^sup Ink4a^ Regulates Fasting-Induced Hepatic Gluconeogenesis Through the PKA-CREB-PGC1[alpha] Pathway</atitle><jtitle>Diabetes (New York, N.Y.)</jtitle><date>2014-10-01</date><risdate>2014</risdate><volume>63</volume><issue>10</issue><spage>3199</spage><pages>3199-</pages><issn>0012-1797</issn><eissn>1939-327X</eissn><coden>DIAEAZ</coden><abstract>Type 2 diabetes (T2D) is hallmarked by insulin resistance, impaired insulin secretion, and increased hepatic glucose production. The worldwide increasing prevalence of T2D calls for efforts to understand its pathogenesis in order to improve disease prevention and management. Recent genome-wide association studies have revealed strong associations between the CDKN2A/B locus and T2D risk. The CDKN2A/B locus contains genes encoding cell cycle inhibitors, including p16..., which have not yet been implicated in the control of hepatic glucose homeostasis. Here, we show that p16... deficiency enhances fasting-induced hepatic glucose production in vivo by increasing the expression of key gluconeogenic genes. p16... downregulation leads to an activation of PKA-CREB-PGC1α signaling through increased phosphorylation of PKA regulatory subunits. Taken together, these results provide evidence that p16... controls fasting glucose homeostasis and could as such be involved in T2D development. (ProQuest: ... denotes formulae/symbols omitted.)</abstract><cop>New York</cop><pub>American Diabetes Association</pub></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0012-1797 |
| ispartof | Diabetes (New York, N.Y.), 2014-10, Vol.63 (10), p.3199 |
| issn | 0012-1797 1939-327X |
| language | eng |
| recordid | cdi_proquest_journals_1638915405 |
| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Ovid Autoload; PubMed Central |
| subjects | Diabetes Fasting Genomics Glucose Homeostasis Liver Phosphorylation |
| title | Cdkn2a/p16^sup Ink4a^ Regulates Fasting-Induced Hepatic Gluconeogenesis Through the PKA-CREB-PGC1[alpha] Pathway |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-15T10%3A49%3A07IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Cdkn2a/p16%5Esup%20Ink4a%5E%20Regulates%20Fasting-Induced%20Hepatic%20Gluconeogenesis%20Through%20the%20PKA-CREB-PGC1%5Balpha%5D%20Pathway&rft.jtitle=Diabetes%20(New%20York,%20N.Y.)&rft.au=Bantubungi,%20Kadiombo&rft.date=2014-10-01&rft.volume=63&rft.issue=10&rft.spage=3199&rft.pages=3199-&rft.issn=0012-1797&rft.eissn=1939-327X&rft.coden=DIAEAZ&rft_id=info:doi/&rft_dat=%3Cproquest%3E3533699441%3C/proquest%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1638915405&rft_id=info:pmid/&rfr_iscdi=true |