Small molecule-mediated stabilization of vesicle-associated helical [alpha]-synuclein inhibits pathogenic misfolding and aggregation

α-synuclein is an abundant presynaptic protein that is important for regulation of synaptic vesicle trafficking, and whose misfolding plays a key role in Parkinson's disease. While α-synuclein is disordered in solution, it folds into a helical conformation when bound to synaptic vesicles. Stabi...

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Veröffentlicht in:	Nature communications 2014-12, Vol.5, p.5857
Hauptverfasser:	Fonseca-ornelas, Luis, Eisbach, Sybille E, Paulat, Maria, Giller, Karin, Fernández, Claudio O, Outeiro, Tiago F, Becker, Stefan, Zweckstetter, Markus
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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