BOLD MRI in the brain of fetal sheep at 3T during experimental hypoxia
Purpose To calculate regional fetal brain oxygen saturation (sO2) during hypoxia in sheep. Materials and Methods Eight pregnant ewes were examined at a 3T MR‐scanner using blood oxygenation level‐dependent magnetic resonance imaging (BOLD‐MRI) to measure signal intensity changes of the fetal brain d...
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| Veröffentlicht in: | Journal of magnetic resonance imaging 2015-01, Vol.41 (1), p.110-116 |
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| creator | Schoennagel, Bjoern P. Yamamura, Jin Fischer, Roland Tavares de Sousa, Manuela Weyhmiller, Marcela Birkelbach, Moritz Kooijman, Hendrik Adam, Gerhard Wedegaertner, Ulrike |
| description | Purpose
To calculate regional fetal brain oxygen saturation (sO2) during hypoxia in sheep.
Materials and Methods
Eight pregnant ewes were examined at a 3T MR‐scanner using blood oxygenation level‐dependent magnetic resonance imaging (BOLD‐MRI) to measure signal intensity changes of the fetal brain during a control period and a period of induced hypoxia. Regions of interest were placed in the fetal cerebrum to assess ΔR2* from GRE signal intensity plateaus (Scontrol, Shypoxia) and the relation between ΔR2* and ΔpO2 was analyzed. A probe was placed surgically in the fetal brain to directly measure local pO2 as a reference standard. Baseline and hypoxic pO2 values were recorded and compared (ΔpO2).
Results
Mean fetal brain pO2 decreased from 14.3 mmHg (95% confidence interval [CI]: 10–19) to 3.4 mmHg (95% CI: 2–5) during hypoxia (mean ΔpO2 = 10.9 mmHg and ΔR2* = −5s−1). A significant correlation between ΔR2* and ΔpO2 was noted (r = 0.93, P |
| doi_str_mv | 10.1002/jmri.24555 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_1636382958</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3527279131</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4685-eb9375451d7682140b0c513ec28abd3152b7889ca63945321943662870e8ff2d3</originalsourceid><addsrcrecordid>eNp9kF1PwjAUhhujEUVv_AGmiXcmw36sH7tUFMSgGIMh8abptk6GsM12RPj3FgdcetWT9DnvefMAcIFRByNEbmYLm3dIyBg7ACeYERIQJvmhnxGjAZZItMCpczOEUBSF7Bi0SEiZQEKegN7daHgPn98GMC9gPTUwttpPZQYzU-s5dFNjKqhrSMcwXdq8-IRmVRmbL0yx-Z-uq3KV6zNwlOm5M-fbtw3eew_j7mMwHPUH3dthkIRcssDEERUsZDgVXBIcohglDFOTEKnjlPrusZAySjSnviglOAop50QKZGSWkZS2wVWTW9nye2lcrWbl0hb-pMKccipJxKSnrhsqsaVz1mSq8oW1XSuM1EaZ2ihTf8o8fLmNXMYLk-7RnSMP4Ab4yedm_U-UevIed6FBs5O72qz2O9p-KS68AjV56Sv0gV4nYkxUSH8BKQOB3w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1636382958</pqid></control><display><type>article</type><title>BOLD MRI in the brain of fetal sheep at 3T during experimental hypoxia</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Wiley Free Content</source><creator>Schoennagel, Bjoern P. ; Yamamura, Jin ; Fischer, Roland ; Tavares de Sousa, Manuela ; Weyhmiller, Marcela ; Birkelbach, Moritz ; Kooijman, Hendrik ; Adam, Gerhard ; Wedegaertner, Ulrike</creator><creatorcontrib>Schoennagel, Bjoern P. ; Yamamura, Jin ; Fischer, Roland ; Tavares de Sousa, Manuela ; Weyhmiller, Marcela ; Birkelbach, Moritz ; Kooijman, Hendrik ; Adam, Gerhard ; Wedegaertner, Ulrike</creatorcontrib><description>Purpose
To calculate regional fetal brain oxygen saturation (sO2) during hypoxia in sheep.
Materials and Methods
Eight pregnant ewes were examined at a 3T MR‐scanner using blood oxygenation level‐dependent magnetic resonance imaging (BOLD‐MRI) to measure signal intensity changes of the fetal brain during a control period and a period of induced hypoxia. Regions of interest were placed in the fetal cerebrum to assess ΔR2* from GRE signal intensity plateaus (Scontrol, Shypoxia) and the relation between ΔR2* and ΔpO2 was analyzed. A probe was placed surgically in the fetal brain to directly measure local pO2 as a reference standard. Baseline and hypoxic pO2 values were recorded and compared (ΔpO2).
Results
Mean fetal brain pO2 decreased from 14.3 mmHg (95% confidence interval [CI]: 10–19) to 3.4 mmHg (95% CI: 2–5) during hypoxia (mean ΔpO2 = 10.9 mmHg and ΔR2* = −5s−1). A significant correlation between ΔR2* and ΔpO2 was noted (r = 0.93, P < 0.001), and conversion of pO2 into sO2 resulted in a linear regression coefficient of (−0.14 ± 0.01)s−1/% (r2 = 0.91).
Conclusion
Measured fetal brain BOLD‐MRI was compared and converted to pO2, followed by calculation of cerebral sO2. J. Magn. Reson. Imaging 2015;41:110–116. © 2013 Wiley Periodicals, Inc.</description><identifier>ISSN: 1053-1807</identifier><identifier>EISSN: 1522-2586</identifier><identifier>DOI: 10.1002/jmri.24555</identifier><identifier>PMID: 24357078</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Animals ; BOLD ; brain ; Brain - pathology ; Female ; Fetal Hypoxia - pathology ; fetal sheep ; Fetus ; hypoxia ; Magnetic resonance imaging ; Magnetic Resonance Imaging - methods ; MRI ; oxygenation ; Pregnancy</subject><ispartof>Journal of magnetic resonance imaging, 2015-01, Vol.41 (1), p.110-116</ispartof><rights>2013 Wiley Periodicals, Inc.</rights><rights>2014 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4685-eb9375451d7682140b0c513ec28abd3152b7889ca63945321943662870e8ff2d3</citedby><cites>FETCH-LOGICAL-c4685-eb9375451d7682140b0c513ec28abd3152b7889ca63945321943662870e8ff2d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjmri.24555$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjmri.24555$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,778,782,1414,1430,27911,27912,45561,45562,46396,46820</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24357078$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schoennagel, Bjoern P.</creatorcontrib><creatorcontrib>Yamamura, Jin</creatorcontrib><creatorcontrib>Fischer, Roland</creatorcontrib><creatorcontrib>Tavares de Sousa, Manuela</creatorcontrib><creatorcontrib>Weyhmiller, Marcela</creatorcontrib><creatorcontrib>Birkelbach, Moritz</creatorcontrib><creatorcontrib>Kooijman, Hendrik</creatorcontrib><creatorcontrib>Adam, Gerhard</creatorcontrib><creatorcontrib>Wedegaertner, Ulrike</creatorcontrib><title>BOLD MRI in the brain of fetal sheep at 3T during experimental hypoxia</title><title>Journal of magnetic resonance imaging</title><addtitle>J. Magn. Reson. Imaging</addtitle><description>Purpose
To calculate regional fetal brain oxygen saturation (sO2) during hypoxia in sheep.
Materials and Methods
Eight pregnant ewes were examined at a 3T MR‐scanner using blood oxygenation level‐dependent magnetic resonance imaging (BOLD‐MRI) to measure signal intensity changes of the fetal brain during a control period and a period of induced hypoxia. Regions of interest were placed in the fetal cerebrum to assess ΔR2* from GRE signal intensity plateaus (Scontrol, Shypoxia) and the relation between ΔR2* and ΔpO2 was analyzed. A probe was placed surgically in the fetal brain to directly measure local pO2 as a reference standard. Baseline and hypoxic pO2 values were recorded and compared (ΔpO2).
Results
Mean fetal brain pO2 decreased from 14.3 mmHg (95% confidence interval [CI]: 10–19) to 3.4 mmHg (95% CI: 2–5) during hypoxia (mean ΔpO2 = 10.9 mmHg and ΔR2* = −5s−1). A significant correlation between ΔR2* and ΔpO2 was noted (r = 0.93, P < 0.001), and conversion of pO2 into sO2 resulted in a linear regression coefficient of (−0.14 ± 0.01)s−1/% (r2 = 0.91).
Conclusion
Measured fetal brain BOLD‐MRI was compared and converted to pO2, followed by calculation of cerebral sO2. J. Magn. Reson. Imaging 2015;41:110–116. © 2013 Wiley Periodicals, Inc.</description><subject>Animals</subject><subject>BOLD</subject><subject>brain</subject><subject>Brain - pathology</subject><subject>Female</subject><subject>Fetal Hypoxia - pathology</subject><subject>fetal sheep</subject><subject>Fetus</subject><subject>hypoxia</subject><subject>Magnetic resonance imaging</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>MRI</subject><subject>oxygenation</subject><subject>Pregnancy</subject><issn>1053-1807</issn><issn>1522-2586</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kF1PwjAUhhujEUVv_AGmiXcmw36sH7tUFMSgGIMh8abptk6GsM12RPj3FgdcetWT9DnvefMAcIFRByNEbmYLm3dIyBg7ACeYERIQJvmhnxGjAZZItMCpczOEUBSF7Bi0SEiZQEKegN7daHgPn98GMC9gPTUwttpPZQYzU-s5dFNjKqhrSMcwXdq8-IRmVRmbL0yx-Z-uq3KV6zNwlOm5M-fbtw3eew_j7mMwHPUH3dthkIRcssDEERUsZDgVXBIcohglDFOTEKnjlPrusZAySjSnviglOAop50QKZGSWkZS2wVWTW9nye2lcrWbl0hb-pMKccipJxKSnrhsqsaVz1mSq8oW1XSuM1EaZ2ihTf8o8fLmNXMYLk-7RnSMP4Ab4yedm_U-UevIed6FBs5O72qz2O9p-KS68AjV56Sv0gV4nYkxUSH8BKQOB3w</recordid><startdate>201501</startdate><enddate>201501</enddate><creator>Schoennagel, Bjoern P.</creator><creator>Yamamura, Jin</creator><creator>Fischer, Roland</creator><creator>Tavares de Sousa, Manuela</creator><creator>Weyhmiller, Marcela</creator><creator>Birkelbach, Moritz</creator><creator>Kooijman, Hendrik</creator><creator>Adam, Gerhard</creator><creator>Wedegaertner, Ulrike</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope></search><sort><creationdate>201501</creationdate><title>BOLD MRI in the brain of fetal sheep at 3T during experimental hypoxia</title><author>Schoennagel, Bjoern P. ; Yamamura, Jin ; Fischer, Roland ; Tavares de Sousa, Manuela ; Weyhmiller, Marcela ; Birkelbach, Moritz ; Kooijman, Hendrik ; Adam, Gerhard ; Wedegaertner, Ulrike</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4685-eb9375451d7682140b0c513ec28abd3152b7889ca63945321943662870e8ff2d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>BOLD</topic><topic>brain</topic><topic>Brain - pathology</topic><topic>Female</topic><topic>Fetal Hypoxia - pathology</topic><topic>fetal sheep</topic><topic>Fetus</topic><topic>hypoxia</topic><topic>Magnetic resonance imaging</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>MRI</topic><topic>oxygenation</topic><topic>Pregnancy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schoennagel, Bjoern P.</creatorcontrib><creatorcontrib>Yamamura, Jin</creatorcontrib><creatorcontrib>Fischer, Roland</creatorcontrib><creatorcontrib>Tavares de Sousa, Manuela</creatorcontrib><creatorcontrib>Weyhmiller, Marcela</creatorcontrib><creatorcontrib>Birkelbach, Moritz</creatorcontrib><creatorcontrib>Kooijman, Hendrik</creatorcontrib><creatorcontrib>Adam, Gerhard</creatorcontrib><creatorcontrib>Wedegaertner, Ulrike</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Journal of magnetic resonance imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schoennagel, Bjoern P.</au><au>Yamamura, Jin</au><au>Fischer, Roland</au><au>Tavares de Sousa, Manuela</au><au>Weyhmiller, Marcela</au><au>Birkelbach, Moritz</au><au>Kooijman, Hendrik</au><au>Adam, Gerhard</au><au>Wedegaertner, Ulrike</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>BOLD MRI in the brain of fetal sheep at 3T during experimental hypoxia</atitle><jtitle>Journal of magnetic resonance imaging</jtitle><addtitle>J. Magn. Reson. Imaging</addtitle><date>2015-01</date><risdate>2015</risdate><volume>41</volume><issue>1</issue><spage>110</spage><epage>116</epage><pages>110-116</pages><issn>1053-1807</issn><eissn>1522-2586</eissn><abstract>Purpose
To calculate regional fetal brain oxygen saturation (sO2) during hypoxia in sheep.
Materials and Methods
Eight pregnant ewes were examined at a 3T MR‐scanner using blood oxygenation level‐dependent magnetic resonance imaging (BOLD‐MRI) to measure signal intensity changes of the fetal brain during a control period and a period of induced hypoxia. Regions of interest were placed in the fetal cerebrum to assess ΔR2* from GRE signal intensity plateaus (Scontrol, Shypoxia) and the relation between ΔR2* and ΔpO2 was analyzed. A probe was placed surgically in the fetal brain to directly measure local pO2 as a reference standard. Baseline and hypoxic pO2 values were recorded and compared (ΔpO2).
Results
Mean fetal brain pO2 decreased from 14.3 mmHg (95% confidence interval [CI]: 10–19) to 3.4 mmHg (95% CI: 2–5) during hypoxia (mean ΔpO2 = 10.9 mmHg and ΔR2* = −5s−1). A significant correlation between ΔR2* and ΔpO2 was noted (r = 0.93, P < 0.001), and conversion of pO2 into sO2 resulted in a linear regression coefficient of (−0.14 ± 0.01)s−1/% (r2 = 0.91).
Conclusion
Measured fetal brain BOLD‐MRI was compared and converted to pO2, followed by calculation of cerebral sO2. J. Magn. Reson. Imaging 2015;41:110–116. © 2013 Wiley Periodicals, Inc.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>24357078</pmid><doi>10.1002/jmri.24555</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals BOLD brain Brain - pathology Female Fetal Hypoxia - pathology fetal sheep Fetus hypoxia Magnetic resonance imaging Magnetic Resonance Imaging - methods MRI oxygenation Pregnancy |
| title | BOLD MRI in the brain of fetal sheep at 3T during experimental hypoxia |
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