SH3BP2 Cherubism Mutation Potentiates TNF-[alpha]-Induced Osteoclastogenesis via NFATc1 and TNF-[alpha]-Mediated Inflammatory Bone Loss

Cherubism (OMIM# 118400) is a genetic disorder with excessive jawbone resorption caused by mutations in SH3 domain binding protein 2 (SH3BP2), a signaling adaptor protein. Studies on the mouse model for cherubism carrying a P416R knock-in (KI) mutation have revealed that mutant SH3BP2 enhances tumor...

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Veröffentlicht in:	Journal of bone and mineral research 2014-12, Vol.29 (12), p.2618
Hauptverfasser:	Mukai, Tomoyuki, Ishida, Shu, Ishikawa, Remi, Yoshitaka, Teruhito, Kittaka, Mizuho, Gallant, Richard, Lin, Yi-Ling, Rottapel, Robert, Brotto, Marco, Reichenberger, Ernst J, Ueki, Yasuyoshi
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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