Comparison Study on Photodynamic Anticancer Activity of Multifunctional Magnetic Particles by Formation of Cations
In this paper, we have synthesized multifunctional magnetic particles (MNPs) using by two different ferrite submicrometer paticles (Fe 3 O 4 @HP and CoFe 2 O 4 @HP) with different surface properties. Two different multifunctional particles have the same particle sizes within the error tolerance of 4...
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| Veröffentlicht in: | IEEE transactions on magnetics 2014-11, Vol.50 (11), p.1-4 |
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| creator | Choi, Kyong-Hoon Choi, Eun-Wook Min, Jeeeun Son, Hyungbin Uhm, Han Sup HaChoi, Eun Park, Bong Joo Jung, Jin-Seung |
| description | In this paper, we have synthesized multifunctional magnetic particles (MNPs) using by two different ferrite submicrometer paticles (Fe 3 O 4 @HP and CoFe 2 O 4 @HP) with different surface properties. Two different multifunctional particles have the same particle sizes within the error tolerance of 4.5%. The concentration measurement of the hematoporphyrin (HP) molecule indicates that the weight of HP molecules bonded to the surface of the Fe 3 O 4 particles is smaller than that of the CoFe 2 O 4 particles. Moreover, we have evaluated their biocompatibilities and photodynamic anticancer activities on mammalian cells. The two MNPs have demonstrated that they both have good biocompatibilities without any cytotoxicity and anticancer activities in the concentration range of 0-50 μg/mL. Specifically, photodynamic-killing activities of both MNPs were measured to be 100% for CoFe 2 O 4 @HP, and were measured to be 37.9 ± 3.5% and 9.2 ± 2.5% for Fe 3 O 4 @HP in 25 and 50 μg/mL of both MNPs. These results suggest that both MNPs can be safely used to for clinical photodynamic cancer therapy, although the CoFe 2 O 4 @HP showed a slightly better photo-killing efficacy compared with the Fe 3 O 4 @HP in prostate cancer. |
| doi_str_mv | 10.1109/TMAG.2014.2324019 |
| format | Article |
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Two different multifunctional particles have the same particle sizes within the error tolerance of 4.5%. The concentration measurement of the hematoporphyrin (HP) molecule indicates that the weight of HP molecules bonded to the surface of the Fe 3 O 4 particles is smaller than that of the CoFe 2 O 4 particles. Moreover, we have evaluated their biocompatibilities and photodynamic anticancer activities on mammalian cells. The two MNPs have demonstrated that they both have good biocompatibilities without any cytotoxicity and anticancer activities in the concentration range of 0-50 μg/mL. Specifically, photodynamic-killing activities of both MNPs were measured to be 100% for CoFe 2 O 4 @HP, and were measured to be 37.9 ± 3.5% and 9.2 ± 2.5% for Fe 3 O 4 @HP in 25 and 50 μg/mL of both MNPs. These results suggest that both MNPs can be safely used to for clinical photodynamic cancer therapy, although the CoFe 2 O 4 @HP showed a slightly better photo-killing efficacy compared with the Fe 3 O 4 @HP in prostate cancer.</description><identifier>ISSN: 0018-9464</identifier><identifier>EISSN: 1941-0069</identifier><identifier>DOI: 10.1109/TMAG.2014.2324019</identifier><identifier>CODEN: IEMGAQ</identifier><language>eng</language><publisher>New York: IEEE</publisher><subject>Educational institutions ; Ferrites ; Magnetic particles ; Magnetism ; Nanoparticles ; Optical surface waves ; Prostate cancer</subject><ispartof>IEEE transactions on magnetics, 2014-11, Vol.50 (11), p.1-4</ispartof><rights>Copyright The Institute of Electrical and Electronics Engineers, Inc. (IEEE) Nov 2014</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c293t-ad5089ee55ab2c4a3c9097438b17b156a7e9c9bfe2eecece815420dba2f312bf3</citedby><cites>FETCH-LOGICAL-c293t-ad5089ee55ab2c4a3c9097438b17b156a7e9c9bfe2eecece815420dba2f312bf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://ieeexplore.ieee.org/document/6971750$$EHTML$$P50$$Gieee$$H</linktohtml><link.rule.ids>314,780,784,796,27924,27925,54758</link.rule.ids><linktorsrc>$$Uhttps://ieeexplore.ieee.org/document/6971750$$EView_record_in_IEEE$$FView_record_in_$$GIEEE</linktorsrc></links><search><creatorcontrib>Choi, Kyong-Hoon</creatorcontrib><creatorcontrib>Choi, Eun-Wook</creatorcontrib><creatorcontrib>Min, Jeeeun</creatorcontrib><creatorcontrib>Son, Hyungbin</creatorcontrib><creatorcontrib>Uhm, Han Sup</creatorcontrib><creatorcontrib>HaChoi, Eun</creatorcontrib><creatorcontrib>Park, Bong Joo</creatorcontrib><creatorcontrib>Jung, Jin-Seung</creatorcontrib><title>Comparison Study on Photodynamic Anticancer Activity of Multifunctional Magnetic Particles by Formation of Cations</title><title>IEEE transactions on magnetics</title><addtitle>TMAG</addtitle><description>In this paper, we have synthesized multifunctional magnetic particles (MNPs) using by two different ferrite submicrometer paticles (Fe 3 O 4 @HP and CoFe 2 O 4 @HP) with different surface properties. Two different multifunctional particles have the same particle sizes within the error tolerance of 4.5%. The concentration measurement of the hematoporphyrin (HP) molecule indicates that the weight of HP molecules bonded to the surface of the Fe 3 O 4 particles is smaller than that of the CoFe 2 O 4 particles. Moreover, we have evaluated their biocompatibilities and photodynamic anticancer activities on mammalian cells. The two MNPs have demonstrated that they both have good biocompatibilities without any cytotoxicity and anticancer activities in the concentration range of 0-50 μg/mL. Specifically, photodynamic-killing activities of both MNPs were measured to be 100% for CoFe 2 O 4 @HP, and were measured to be 37.9 ± 3.5% and 9.2 ± 2.5% for Fe 3 O 4 @HP in 25 and 50 μg/mL of both MNPs. These results suggest that both MNPs can be safely used to for clinical photodynamic cancer therapy, although the CoFe 2 O 4 @HP showed a slightly better photo-killing efficacy compared with the Fe 3 O 4 @HP in prostate cancer.</description><subject>Educational institutions</subject><subject>Ferrites</subject><subject>Magnetic particles</subject><subject>Magnetism</subject><subject>Nanoparticles</subject><subject>Optical surface waves</subject><subject>Prostate cancer</subject><issn>0018-9464</issn><issn>1941-0069</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>RIE</sourceid><recordid>eNo9kF1LwzAUhoMoOKc_QLwJeN2Zk4-2uSzDTWHDgfO6pGmqHW0zk1bovzd1Q87F-eB5Xw4vQvdAFgBEPu232XpBCfAFZZQTkBdoBpJDREgsL9GMEEgjyWN-jW68P4SVCyAz5Ja2PSpXe9vh934oRxyG3ZftbTl2qq01zrq-1qrTxuFM9_VP3Qemwtuh6etq6MLJdqrBW_XZmUDinXKhNcbjYsQr61o1EZNk-Tf5W3RVqcabu3Ofo4_V8375Em3e1q_LbBNpKlkfqVKQVBojhCqo5oppSWTCWVpAUoCIVWKklkVlqDE6VAqCU1IWilYMaFGxOXo8-R6d_R6M7_ODHVz41ecQMwKJiFMRKDhR2lnvnanyo6tb5cYcSD5Fm0_R5lO0-TnaoHk4aWpjzD8fyyR4EvYLuaJ3aA</recordid><startdate>201411</startdate><enddate>201411</enddate><creator>Choi, Kyong-Hoon</creator><creator>Choi, Eun-Wook</creator><creator>Min, Jeeeun</creator><creator>Son, Hyungbin</creator><creator>Uhm, Han Sup</creator><creator>HaChoi, Eun</creator><creator>Park, Bong Joo</creator><creator>Jung, Jin-Seung</creator><general>IEEE</general><general>The Institute of Electrical and Electronics Engineers, Inc. (IEEE)</general><scope>97E</scope><scope>RIA</scope><scope>RIE</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SP</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope></search><sort><creationdate>201411</creationdate><title>Comparison Study on Photodynamic Anticancer Activity of Multifunctional Magnetic Particles by Formation of Cations</title><author>Choi, Kyong-Hoon ; Choi, Eun-Wook ; Min, Jeeeun ; Son, Hyungbin ; Uhm, Han Sup ; HaChoi, Eun ; Park, Bong Joo ; Jung, Jin-Seung</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c293t-ad5089ee55ab2c4a3c9097438b17b156a7e9c9bfe2eecece815420dba2f312bf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Educational institutions</topic><topic>Ferrites</topic><topic>Magnetic particles</topic><topic>Magnetism</topic><topic>Nanoparticles</topic><topic>Optical surface waves</topic><topic>Prostate cancer</topic><toplevel>online_resources</toplevel><creatorcontrib>Choi, Kyong-Hoon</creatorcontrib><creatorcontrib>Choi, Eun-Wook</creatorcontrib><creatorcontrib>Min, Jeeeun</creatorcontrib><creatorcontrib>Son, Hyungbin</creatorcontrib><creatorcontrib>Uhm, Han Sup</creatorcontrib><creatorcontrib>HaChoi, Eun</creatorcontrib><creatorcontrib>Park, Bong Joo</creatorcontrib><creatorcontrib>Jung, Jin-Seung</creatorcontrib><collection>IEEE All-Society Periodicals Package (ASPP) 2005-present</collection><collection>IEEE All-Society Periodicals Package (ASPP) 1998-Present</collection><collection>IEEE Electronic Library (IEL)</collection><collection>CrossRef</collection><collection>Electronics & Communications Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>IEEE transactions on magnetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Choi, Kyong-Hoon</au><au>Choi, Eun-Wook</au><au>Min, Jeeeun</au><au>Son, Hyungbin</au><au>Uhm, Han Sup</au><au>HaChoi, Eun</au><au>Park, Bong Joo</au><au>Jung, Jin-Seung</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison Study on Photodynamic Anticancer Activity of Multifunctional Magnetic Particles by Formation of Cations</atitle><jtitle>IEEE transactions on magnetics</jtitle><stitle>TMAG</stitle><date>2014-11</date><risdate>2014</risdate><volume>50</volume><issue>11</issue><spage>1</spage><epage>4</epage><pages>1-4</pages><issn>0018-9464</issn><eissn>1941-0069</eissn><coden>IEMGAQ</coden><abstract>In this paper, we have synthesized multifunctional magnetic particles (MNPs) using by two different ferrite submicrometer paticles (Fe 3 O 4 @HP and CoFe 2 O 4 @HP) with different surface properties. Two different multifunctional particles have the same particle sizes within the error tolerance of 4.5%. The concentration measurement of the hematoporphyrin (HP) molecule indicates that the weight of HP molecules bonded to the surface of the Fe 3 O 4 particles is smaller than that of the CoFe 2 O 4 particles. Moreover, we have evaluated their biocompatibilities and photodynamic anticancer activities on mammalian cells. The two MNPs have demonstrated that they both have good biocompatibilities without any cytotoxicity and anticancer activities in the concentration range of 0-50 μg/mL. Specifically, photodynamic-killing activities of both MNPs were measured to be 100% for CoFe 2 O 4 @HP, and were measured to be 37.9 ± 3.5% and 9.2 ± 2.5% for Fe 3 O 4 @HP in 25 and 50 μg/mL of both MNPs. These results suggest that both MNPs can be safely used to for clinical photodynamic cancer therapy, although the CoFe 2 O 4 @HP showed a slightly better photo-killing efficacy compared with the Fe 3 O 4 @HP in prostate cancer.</abstract><cop>New York</cop><pub>IEEE</pub><doi>10.1109/TMAG.2014.2324019</doi><tpages>4</tpages></addata></record> |
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| subjects | Educational institutions Ferrites Magnetic particles Magnetism Nanoparticles Optical surface waves Prostate cancer |
| title | Comparison Study on Photodynamic Anticancer Activity of Multifunctional Magnetic Particles by Formation of Cations |
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