A cell-intrinsic role for TLR2–MYD88 in intestinal and breast epithelia and oncogenesis

It has been postulated that there is a link between inflammation and cancer. Here we describe a role for cell-intrinsic toll-like receptor-2 (TLR2; which is involved in inflammatory response) signalling in normal intestinal and mammary epithelial cells and oncogenesis. The downstream effectors of TL...

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Veröffentlicht in:	Nature cell biology 2014-12, Vol.16 (12), p.1238-1248
Hauptverfasser:	Scheeren, Ferenc A., Kuo, Angera H., van Weele, Linda J., Cai, Shang, Glykofridis, Iris, Sikandar, Shaheen S., Zabala, Maider, Qian, Dalong, Lam, Jessica S., Johnston, Darius, Volkmer, Jens P., Sahoo, Debashis, van de Rijn, Matt, Dirbas, Frederick M., Somlo, George, Kalisky, Tomer, Rothenberg, Michael E., Quake, Stephen R., Clarke, Michael F.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/31 38/35 38/39 631/67 631/67/70 631/80/86 64/110 82/51 Animals Antigens, Neoplasm - metabolism Breast - metabolism Breast - pathology Breast cancer Breast Neoplasms - genetics Breast Neoplasms - pathology Cancer Cancer Research Carcinogenesis - genetics Carcinogenesis - metabolism Cell Adhesion Molecules - metabolism Cell Biology Colitis - chemically induced Colitis - pathology Colon Colonic Neoplasms - genetics Colonic Neoplasms - pathology Development and progression Developmental Biology Dextran Sulfate Drinking water Epithelial Cell Adhesion Molecule Epithelium - pathology Female Gastrointestinal cancer Genetic aspects HEK293 Cells Humans Inflammatory bowel disease Interleukin-1 Receptor-Associated Kinases - antagonists & inhibitors Interleukin-1 Receptor-Associated Kinases - genetics Intestinal Mucosa - metabolism Intestinal Mucosa - pathology Leukocyte Common Antigens - genetics Life Sciences Ligands Lipopolysaccharide Receptors - metabolism Mice Mice, Inbred C57BL Mice, Knockout Myeloid Differentiation Factor 88 - antagonists & inhibitors Myeloid Differentiation Factor 88 - genetics Myeloid Differentiation Factor 88 - metabolism Neoplasm Transplantation Oncology Properties Proteins Receptors, G-Protein-Coupled - metabolism Regeneration - genetics RNA Interference RNA, Small Interfering Signal Transduction Stem Cells Toll-Like Receptor 2 - antagonists & inhibitors Toll-Like Receptor 2 - genetics Toll-Like Receptor 2 - metabolism Toll-like receptors Tumor Cells, Cultured
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