Use of PER977 to Reverse the Anticoagulant Effect of Edoxaban

Among 80 healthy persons who had received a single dose of edoxaban, the whole-blood clotting time was reduced significantly more rapidly in those who received the novel small molecule PER977 than in controls who were not given PER977. To the Editor: New target-specific oral anticoagulants are limit...

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Veröffentlicht in:	The New England journal of medicine 2014-11, Vol.371 (22), p.2141-2142
Hauptverfasser:	Ansell, Jack E, Bakhru, Sasha H, Laulicht, Bryan E, Steiner, Solomon S, Grosso, Michael, Brown, Karen, Dishy, Victor, Noveck, Robert J, Costin, James C
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticoagulants Arginine - analogs & derivatives Arginine - pharmacokinetics Arginine - pharmacology Blood coagulation Blood Coagulation - drug effects Clotting Factor Xa Inhibitors Heparin Antagonists - pharmacokinetics Heparin Antagonists - pharmacology Humans Pharmaceuticals Pharmacology Piperazines - pharmacokinetics Piperazines - pharmacology Pyridines - antagonists & inhibitors Thiazoles - antagonists & inhibitors
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