[beta]-Functionalization of Carboxylic Anhydrides with [beta]-Alkyl Substituents through Carbene Organocatalysis

The first NHC-catalyzed functionalization of carboxylic anhydrides is described. In this reaction, the [beta]carbon behaves as a nucleophilic carbon and undergoes asymmetric reactions with electrophiles. Anhydrides with challenging [beta]-alkyl substituents work effectively.

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Veröffentlicht in:	Angewandte Chemie 2014-12, Vol.126 (49), p.13724
Hauptverfasser:	Jin, Zhichao, Chen, Shaojin, Wang, Yuhuang, Zheng, Pengcheng, Yang, Song, Chi, Yonggui Robin
Format:	Artikel
Sprache:	ger
Schlagworte:	Chemistry
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creator	Jin, Zhichao Chen, Shaojin Wang, Yuhuang Zheng, Pengcheng Yang, Song Chi, Yonggui Robin
description	The first NHC-catalyzed functionalization of carboxylic anhydrides is described. In this reaction, the [beta]carbon behaves as a nucleophilic carbon and undergoes asymmetric reactions with electrophiles. Anhydrides with challenging [beta]-alkyl substituents work effectively.
doi_str_mv	10.1002/ange.201408604
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source	Wiley Online Library Journals Frontfile Complete
subjects	Chemistry
title	[beta]-Functionalization of Carboxylic Anhydrides with [beta]-Alkyl Substituents through Carbene Organocatalysis
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