MicroRNA-21 Attenuates Renal Ischemia Reperfusion Injury via Targeting Caspase Signaling in Mice

Background: MicroRNAs (miR) have come into focus as powerful regulators of gene expression and potential diagnostic tools during renal ischemia reperfusion injury (IRI). The aim of this study was to investigate the molecular regulation and function of miR-21, and to analyze the relationship between...

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Veröffentlicht in:	American journal of nephrology 2014-01, Vol.40 (3), p.215-223
Hauptverfasser:	Hu, Honglin, Jiang, Wei, Xi, Xiaoqing, Zou, Cong, Ye, Zhenfeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis Regulatory Proteins - metabolism Blood Urea Nitrogen Caspase 3 - metabolism Caspase 8 - metabolism Caspases - metabolism Disease Models, Animal Gene Expression Profiling Interleukin-18 - blood Ischemia - metabolism Kidney - metabolism Kidney - pathology Male Mice Mice, Inbred BALB C MicroRNAs - genetics MicroRNAs - metabolism Original Report: Laboratory Investigation Random Allocation Reperfusion Injury - pathology RNA-Binding Proteins - metabolism Signal Transduction Up-Regulation
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