Non-targeted radiation effectsin vivo: A critical glance of the future in radiobiology
Radiation-induced bystander effects (RIBE), demonstrate the induction of biological non-targeted effects in cells which have not directly hit by radiation or by free radicals produced by ionization events. Although RIBE have been demonstrated using a variety of biological endpoints the mechanism(s)...
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| Veröffentlicht in: | Cancer letters 2015-01, Vol.356 (1), p.34 |
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| container_title | Cancer letters |
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| creator | Hatzi, Vasiliki I Laskaratou, Danae A Mavragani, Ifigeneia V Nikitaki, Zacharenia Mangelis, Anastasios Panayiotidis, Mihalis I Pantelias, Gabriel E Terzoudi, Georgia I Georgakilas, Alexandros G |
| description | Radiation-induced bystander effects (RIBE), demonstrate the induction of biological non-targeted effects in cells which have not directly hit by radiation or by free radicals produced by ionization events. Although RIBE have been demonstrated using a variety of biological endpoints the mechanism(s) of this phenomenon still remain unclear. The controversial results of thein vitroRIBE and the evidence of non-targeted effects in variousin vivosystems are discussed. The experimental evidence on RIBE, indicate that a more analytical and mechanistic in depth approach is needed to secure an answer to one of the most intriguing questions in radiobiology. |
| doi_str_mv | 10.1016/j.canlet.2013.11.018 |
| format | Article |
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| identifier | ISSN: 0304-3835 |
| ispartof | Cancer letters, 2015-01, Vol.356 (1), p.34 |
| issn | 0304-3835 1872-7980 |
| language | eng |
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings |
| subjects | Apoptosis Charged particles Deoxyribonucleic acid DNA DNA methylation Free radicals Gene expression Metabolism Studies |
| title | Non-targeted radiation effectsin vivo: A critical glance of the future in radiobiology |
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