GW25-e0604 HO-1 attenuates intestinal ischemic injury secondary to MI-induced HF in rats
Objectives The development of heart failure (HF) is associated with myocardial remodeling after myocardial infarction (MI).HF reduces cardiac function and decreases splanchnic blood flow to the intestine, resulting in ischemia in the villi and damage to the intestinal barrier.HO-1 is a stress-induci...
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| Veröffentlicht in: | Journal of the American College of Cardiology 2014-10, Vol.64 (16), p.C84-C84 |
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| container_end_page | C84 |
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| container_issue | 16 |
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| container_title | Journal of the American College of Cardiology |
| container_volume | 64 |
| creator | Zhuokun, Gan Zhang, Liping Bai, Jie Tan, Guojuan Li, Xiaoxia Xu, Yaping Zhou, Yu Gong, Meiliang Lin, Mosi Zhang, Li |
| description | Objectives The development of heart failure (HF) is associated with myocardial remodeling after myocardial infarction (MI).HF reduces cardiac function and decreases splanchnic blood flow to the intestine, resulting in ischemia in the villi and damage to the intestinal barrier.HO-1 is a stress-inducible protein that exhibits potential anti-inflammatory effects and is known to be cytoprotective which has been indicated in "acute phase" during post ischemic incidence, both cardiac and intestinal, but rarely been reported in intestinal ischemic injury secondary to MI-induced HF, besides, over 2 months' observation. |
| doi_str_mv | 10.1016/j.jacc.2014.06.391 |
| format | Article |
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| subjects | Carbon monoxide Cardiology Cardiovascular Heart attacks Heart failure Internal Medicine Morphology Rodents |
| title | GW25-e0604 HO-1 attenuates intestinal ischemic injury secondary to MI-induced HF in rats |
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