InvasiveEscherichia colivaccines expressingBrucella melitensisouter membrane proteins 31 or 16 or periplasmic protein BP26 confer protection in mice challenged withB. melitensis
Highlights * Non-pathogenic invasiveEscherichia coliused as a vaccine platform to mimicBrucella melitensis. * InvasiveE. coliexpressingB. melitensisOmps induce IFN-γ and cytotoxic T cells. * Vaccine platform expressing Omps induceantibodies and T cell proliferation. * InvasiveE. coliexpressing Omps...
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Veröffentlicht in: | Vaccine 2012-06, Vol.30 (27), p.4017 |
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container_title | Vaccine |
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creator | Gupta, VK Radhakrishnan, G Harms, J Splitter, G |
description | Highlights * Non-pathogenic invasiveEscherichia coliused as a vaccine platform to mimicBrucella melitensis. * InvasiveE. coliexpressingB. melitensisOmps induce IFN-γ and cytotoxic T cells. * Vaccine platform expressing Omps induceantibodies and T cell proliferation. * InvasiveE. coliexpressing Omps protect againstB. melitensischallenge. |
doi_str_mv | 10.1016/j.vaccine.2012.04.036 |
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subjects | Animals Bacteria Bacteriology Brucellosis E coli Genes Genetic engineering Plasmids Proteins Vaccines |
title | InvasiveEscherichia colivaccines expressingBrucella melitensisouter membrane proteins 31 or 16 or periplasmic protein BP26 confer protection in mice challenged withB. melitensis |
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