InvasiveEscherichia colivaccines expressingBrucella melitensisouter membrane proteins 31 or 16 or periplasmic protein BP26 confer protection in mice challenged withB. melitensis

Highlights * Non-pathogenic invasiveEscherichia coliused as a vaccine platform to mimicBrucella melitensis. * InvasiveE. coliexpressingB. melitensisOmps induce IFN-γ and cytotoxic T cells. * Vaccine platform expressing Omps induceantibodies and T cell proliferation. * InvasiveE. coliexpressing Omps...

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Veröffentlicht in:Vaccine 2012-06, Vol.30 (27), p.4017
Hauptverfasser: Gupta, VK, Radhakrishnan, G, Harms, J, Splitter, G
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container_issue 27
container_start_page 4017
container_title Vaccine
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creator Gupta, VK
Radhakrishnan, G
Harms, J
Splitter, G
description Highlights * Non-pathogenic invasiveEscherichia coliused as a vaccine platform to mimicBrucella melitensis. * InvasiveE. coliexpressingB. melitensisOmps induce IFN-γ and cytotoxic T cells. * Vaccine platform expressing Omps induceantibodies and T cell proliferation. * InvasiveE. coliexpressing Omps protect againstB. melitensischallenge.
doi_str_mv 10.1016/j.vaccine.2012.04.036
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subjects Animals
Bacteria
Bacteriology
Brucellosis
E coli
Genes
Genetic engineering
Plasmids
Proteins
Vaccines
title InvasiveEscherichia colivaccines expressingBrucella melitensisouter membrane proteins 31 or 16 or periplasmic protein BP26 confer protection in mice challenged withB. melitensis
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