High-fat-diet-mediated dysbiosis promotes intestinal carcinogenesis independently of obesity

A high-fat diet promotes intestinal tumorigenesis independently of obesity in a mouse model with oncogene activation, by changing the composition of the gut microbiota and altering immune regulation. Fatty diets and cancer Western diets, particularly those high in fats, have been linked to gastroint...

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Veröffentlicht in:	Nature (London) 2014-10, Vol.514 (7523), p.508-512
Hauptverfasser:	Schulz, Manon D., Atay, Çiğdem, Heringer, Jessica, Romrig, Franziska K., Schwitalla, Sarah, Aydin, Begüm, Ziegler, Paul K., Varga, Julia, Reindl, Wolfgang, Pommerenke, Claudia, Salinas-Riester, Gabriela, Böck, Andreas, Alpert, Carl, Blaut, Michael, Polson, Sara C., Brandl, Lydia, Kirchner, Thomas, Greten, Florian R., Polson, Shawn W., Arkan, Melek C.
Format:	Artikel
Sprache:	eng
Schlagworte:	38/1 38/61 38/91 631/67 64/60 Animals Anti-Bacterial Agents - pharmacology Antibiotics Antigens Bacteria Bone marrow Butyrates - pharmacology Cancer Carcinogenesis Carcinogenesis - drug effects Causes of Complications and side effects Diet Diet, High-Fat - adverse effects Dietary Fats - adverse effects Disease Progression Dysbiosis Dysbiosis - chemically induced Dysbiosis - microbiology Environmental factors Gastrointestinal cancer Gene expression Health aspects Humanities and Social Sciences Intestinal Mucosa - immunology Intestinal Neoplasms - chemically induced Intestinal Neoplasms - microbiology Intestines - drug effects Intestines - microbiology Ketogenic diet letter Mice multidisciplinary Obesity Obesity - chemically induced Obesity - microbiology Pathogenesis Pattern recognition Prebiotics Proteins Risk factors Rodents Science Small intestine Tumorigenesis Tumors
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