Treatment of Radiation-Induced Cognitive Decline
Opinion statement Radiation-induced cognitive decline in cancer survivors who have received brain radiotherapy is an insidious problem with worsening severity over time. Because of improved survival with modern therapies, an increasing number of long term survivors are affected with limited options...
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| Veröffentlicht in: | Current treatment options in oncology 2014-12, Vol.15 (4), p.539-550 |
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| creator | Attia, Albert Page, Brandi R. Lesser, Glenn J. Chan, Michael |
| description | Opinion statement
Radiation-induced cognitive decline in cancer survivors who have received brain radiotherapy is an insidious problem with worsening severity over time. Because of improved survival with modern therapies, an increasing number of long term survivors are affected with limited options for treatment once diagnosed. Recently there has been enthusiasm for evaluating new approaches to prevent the onset of radiation-induced cognitive decline. Clinical trials have assessed the role of pharmaceuticals such as memantine and donepezil in ameliorating the cognitive effects of brain irradiation. Radiosurgery, when clinically appropriate, allows for the avoidance or postponement of whole brain radiotherapy in some patients with brain metastases. Hippocampal-sparing intensity modulated radiotherapy has been proposed as a means of avoiding damage to regions of adult neurogenesis. Finally, cytoprotective agents are being investigated that target the molecular pathways that lead to brain injury and the resultant cognitive decline. |
| doi_str_mv | 10.1007/s11864-014-0307-3 |
| format | Article |
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Radiation-induced cognitive decline in cancer survivors who have received brain radiotherapy is an insidious problem with worsening severity over time. Because of improved survival with modern therapies, an increasing number of long term survivors are affected with limited options for treatment once diagnosed. Recently there has been enthusiasm for evaluating new approaches to prevent the onset of radiation-induced cognitive decline. Clinical trials have assessed the role of pharmaceuticals such as memantine and donepezil in ameliorating the cognitive effects of brain irradiation. Radiosurgery, when clinically appropriate, allows for the avoidance or postponement of whole brain radiotherapy in some patients with brain metastases. Hippocampal-sparing intensity modulated radiotherapy has been proposed as a means of avoiding damage to regions of adult neurogenesis. Finally, cytoprotective agents are being investigated that target the molecular pathways that lead to brain injury and the resultant cognitive decline.</description><identifier>ISSN: 1527-2729</identifier><identifier>EISSN: 1534-6277</identifier><identifier>EISSN: 1534-5277</identifier><identifier>DOI: 10.1007/s11864-014-0307-3</identifier><identifier>PMID: 25228143</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Brain Neoplasms - complications ; Brain Neoplasms - radiotherapy ; Cognition Disorders - diagnosis ; Cognition Disorders - epidemiology ; Cognition Disorders - etiology ; Cognition Disorders - therapy ; Cognitive Dysfunction - diagnosis ; Cognitive Dysfunction - epidemiology ; Cognitive Dysfunction - etiology ; Cognitive Dysfunction - therapy ; Cranial Irradiation - adverse effects ; Humans ; Medicine ; Medicine & Public Health ; Neuro-oncology (GJ Lesser ; Oncology ; Prognosis ; Section Editor</subject><ispartof>Current treatment options in oncology, 2014-12, Vol.15 (4), p.539-550</ispartof><rights>Springer Science+Business Media New York 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-c9aa5d233a24c6f6cdf61a142132813d93d2e60d36a459548260a30e594158ce3</citedby><cites>FETCH-LOGICAL-c438t-c9aa5d233a24c6f6cdf61a142132813d93d2e60d36a459548260a30e594158ce3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11864-014-0307-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11864-014-0307-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27929,27930,41493,42562,51324</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25228143$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Attia, Albert</creatorcontrib><creatorcontrib>Page, Brandi R.</creatorcontrib><creatorcontrib>Lesser, Glenn J.</creatorcontrib><creatorcontrib>Chan, Michael</creatorcontrib><title>Treatment of Radiation-Induced Cognitive Decline</title><title>Current treatment options in oncology</title><addtitle>Curr. Treat. Options in Oncol</addtitle><addtitle>Curr Treat Options Oncol</addtitle><description>Opinion statement
Radiation-induced cognitive decline in cancer survivors who have received brain radiotherapy is an insidious problem with worsening severity over time. Because of improved survival with modern therapies, an increasing number of long term survivors are affected with limited options for treatment once diagnosed. Recently there has been enthusiasm for evaluating new approaches to prevent the onset of radiation-induced cognitive decline. Clinical trials have assessed the role of pharmaceuticals such as memantine and donepezil in ameliorating the cognitive effects of brain irradiation. Radiosurgery, when clinically appropriate, allows for the avoidance or postponement of whole brain radiotherapy in some patients with brain metastases. Hippocampal-sparing intensity modulated radiotherapy has been proposed as a means of avoiding damage to regions of adult neurogenesis. Finally, cytoprotective agents are being investigated that target the molecular pathways that lead to brain injury and the resultant cognitive decline.</description><subject>Brain Neoplasms - complications</subject><subject>Brain Neoplasms - radiotherapy</subject><subject>Cognition Disorders - diagnosis</subject><subject>Cognition Disorders - epidemiology</subject><subject>Cognition Disorders - etiology</subject><subject>Cognition Disorders - therapy</subject><subject>Cognitive Dysfunction - diagnosis</subject><subject>Cognitive Dysfunction - epidemiology</subject><subject>Cognitive Dysfunction - etiology</subject><subject>Cognitive Dysfunction - therapy</subject><subject>Cranial Irradiation - adverse effects</subject><subject>Humans</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neuro-oncology (GJ Lesser</subject><subject>Oncology</subject><subject>Prognosis</subject><subject>Section Editor</subject><issn>1527-2729</issn><issn>1534-6277</issn><issn>1534-5277</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kE1LAzEQhoMotlZ_gBdZ8BzNZJLs7lHqV6EgSD2HmGTLlna3JruC_94sW8WLh2EG5v2Ah5BLYDfAWH4bAQolKIM0yHKKR2QKEgVVPM-Ph5vnlOe8nJCzGDeMcSlYeUomXHJegMApYavgTbfzTZe1VfZqXG26um3oonG99S6bt-um7upPn917u60bf05OKrON_uKwZ-Tt8WE1f6bLl6fF_G5JrcCio7Y0RjqOaLiwqlLWVQoMCA6YmtGV6LhXzKEyQpZSFFwxg8zLUoAsrMcZuR5z96H96H3s9KbtQ5MqNSgoEOWQNSMwqmxoYwy-0vtQ70z40sD0wEiPjHRipAdGGpPn6pDcv--8-3X8QEkCPgpiejVrH_5U_5v6DTVBbrg</recordid><startdate>20141201</startdate><enddate>20141201</enddate><creator>Attia, Albert</creator><creator>Page, Brandi R.</creator><creator>Lesser, Glenn J.</creator><creator>Chan, Michael</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20141201</creationdate><title>Treatment of Radiation-Induced Cognitive Decline</title><author>Attia, Albert ; Page, Brandi R. ; Lesser, Glenn J. ; Chan, Michael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-c9aa5d233a24c6f6cdf61a142132813d93d2e60d36a459548260a30e594158ce3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Brain Neoplasms - complications</topic><topic>Brain Neoplasms - radiotherapy</topic><topic>Cognition Disorders - diagnosis</topic><topic>Cognition Disorders - epidemiology</topic><topic>Cognition Disorders - etiology</topic><topic>Cognition Disorders - therapy</topic><topic>Cognitive Dysfunction - diagnosis</topic><topic>Cognitive Dysfunction - epidemiology</topic><topic>Cognitive Dysfunction - etiology</topic><topic>Cognitive Dysfunction - therapy</topic><topic>Cranial Irradiation - adverse effects</topic><topic>Humans</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neuro-oncology (GJ Lesser</topic><topic>Oncology</topic><topic>Prognosis</topic><topic>Section Editor</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Attia, Albert</creatorcontrib><creatorcontrib>Page, Brandi R.</creatorcontrib><creatorcontrib>Lesser, Glenn J.</creatorcontrib><creatorcontrib>Chan, Michael</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Proquest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Current treatment options in oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Attia, Albert</au><au>Page, Brandi R.</au><au>Lesser, Glenn J.</au><au>Chan, Michael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Treatment of Radiation-Induced Cognitive Decline</atitle><jtitle>Current treatment options in oncology</jtitle><stitle>Curr. Treat. Options in Oncol</stitle><addtitle>Curr Treat Options Oncol</addtitle><date>2014-12-01</date><risdate>2014</risdate><volume>15</volume><issue>4</issue><spage>539</spage><epage>550</epage><pages>539-550</pages><issn>1527-2729</issn><eissn>1534-6277</eissn><eissn>1534-5277</eissn><abstract>Opinion statement
Radiation-induced cognitive decline in cancer survivors who have received brain radiotherapy is an insidious problem with worsening severity over time. Because of improved survival with modern therapies, an increasing number of long term survivors are affected with limited options for treatment once diagnosed. Recently there has been enthusiasm for evaluating new approaches to prevent the onset of radiation-induced cognitive decline. Clinical trials have assessed the role of pharmaceuticals such as memantine and donepezil in ameliorating the cognitive effects of brain irradiation. Radiosurgery, when clinically appropriate, allows for the avoidance or postponement of whole brain radiotherapy in some patients with brain metastases. Hippocampal-sparing intensity modulated radiotherapy has been proposed as a means of avoiding damage to regions of adult neurogenesis. Finally, cytoprotective agents are being investigated that target the molecular pathways that lead to brain injury and the resultant cognitive decline.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>25228143</pmid><doi>10.1007/s11864-014-0307-3</doi><tpages>12</tpages></addata></record> |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Brain Neoplasms - complications Brain Neoplasms - radiotherapy Cognition Disorders - diagnosis Cognition Disorders - epidemiology Cognition Disorders - etiology Cognition Disorders - therapy Cognitive Dysfunction - diagnosis Cognitive Dysfunction - epidemiology Cognitive Dysfunction - etiology Cognitive Dysfunction - therapy Cranial Irradiation - adverse effects Humans Medicine Medicine & Public Health Neuro-oncology (GJ Lesser Oncology Prognosis Section Editor |
| title | Treatment of Radiation-Induced Cognitive Decline |
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