Intestinal permeability, gut-bacterial dysbiosis, and behavioral markers of alcohol-dependence severity

Alcohol dependence has traditionally been considered a brain disorder. Alteration in the composition of the gut microbiota has recently been shown to be present in psychiatric disorders, which suggests the possibility of gut-to-brain interactions in the development of alcohol dependence. The aim of...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2014-10, Vol.111 (42), p.14971-14971
Hauptverfasser:	Leclercq, Sophie, Matamoros, Sébastien, Cani, Patrice D., Neyrinck, Audrey M., Jamar, François, Stärkel, Peter, Windey, Karen, Tremaroli, Valentina, Bäckhed, Fredrik, Verbeke, Kristin, de Timary, Philippe, Delzenne, Nathalie M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Affect alcohol abuse alcohol dependence alcohol drinking Alcoholism Alcoholism - complications Alcoholism - microbiology alcohols Anxiety Anxiety - complications BARRIER FUNCTION behavior Bifidobacterium Biological Sciences Biomarkers Biopsy BRAIN Clinical Medicine craving Depression - complications Digestive system Dysbiosis - microbiology EPITHELIAL BARRIER ETHANOL Feces Female gastrointestinal system Gastrointestinal Tract - microbiology gut microbiota gut permeability gut-brain axis Humans intestinal microorganisms Intestines - microbiology Klinisk medicin Lactobacillus LEAKY GUT Liver - pathology LIVER-DISEASE Male MECHANISM Mental depression METABOLITES Metabolome MICROBIOTA Middle Aged Permeability PNAS Plus PNAS Plus Significance Statements POSSIBLE PROBIOTIC BACTERIA RNA, Ribosomal, 16S - analysis Volatile Organic Compounds - analysis
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