Lycopodium Alkaloids from Huperzia serrata

Three new lycopodium alkaloids, huperserramines A–C (1–3, resp.), along with 15 known ones, lycopodine‐6α,11α‐diol (4), lycoposerramine H (5), lycoposerramine I (6), lycopodine‐6α‐ol (7), lycoposerramine M (8), diphaladine A (9), lycoposerramine K (10), lycoposerramine W (11), huperzine M (12), luci...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Helvetica chimica acta 2014-10, Vol.97 (10), p.1433-1439
Hauptverfasser:	Ying, You-Min, Liu, Xiao-Sa, Tong, Cui-Ping, Wang, Jian-Wei, Zhan, Zha-Jun, Shan, Wei-Guang
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholinesterase Alkaloids Huperzia serrata Lycopodium alkaloids α-Glucosidase
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

container_end_page	1439
container_issue	10
container_start_page	1433
container_title	Helvetica chimica acta
container_volume	97
creator	Ying, You-Min Liu, Xiao-Sa Tong, Cui-Ping Wang, Jian-Wei Zhan, Zha-Jun Shan, Wei-Guang
description	Three new lycopodium alkaloids, huperserramines A–C (1–3, resp.), along with 15 known ones, lycopodine‐6α,11α‐diol (4), lycoposerramine H (5), lycoposerramine I (6), lycopodine‐6α‐ol (7), lycoposerramine M (8), diphaladine A (9), lycoposerramine K (10), lycoposerramine W (11), huperzine M (12), luciduline (13), phlegmariuine N (14), huperzine A (15), huperzine B (16), lycodine (17), and lycoposerramine R (18), were isolated from the whole plant of Huperzia serrata. Their structures were established by spectroscopic methods, including 2D‐NMR and MS analyses. All the isolates were evaluated for their inhibitory effects on acetylcholinesterase (AChE) and α‐glucosidase. As a result, lycopodine‐6α,11α‐diol (4) exhibited more potent α‐glucosidase inhibitory activity (IC50 148±5.5 μM) than the positive control acarbose (IC50 376.3±2.7 μM).
doi_str_mv	10.1002/hlca.201400015
format	Article
fullrecord	<record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_1613910393</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3465317461</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3555-634d1a5d047a701842ac7d8f76eedb7eefa15948e6731e26485ece1c007f1bc43</originalsourceid><addsrcrecordid>eNqFkE1Lw0AQhhdRsFavngPehNSZ7G42OZaqrRAqgl-3ZbuZYNrUxN0Grb_elEjx5mlgeJ55mZexc4QRAkRXb5U1owhQAADKAzZAGUVhFCt5yAbdKgkB09djduL9skPSFNSAXWZbWzd1XrbrYFytTFWXuQ8KV6-DWduQ-y5N4Mk5szGn7Kgwlaez3zlkT7c3j5NZmN1P7ybjLLRcShnGXORoZA5CGdWlishYlSeFionyhSIqDMpUJBQrjhTFIpFkCS2AKnBhBR-yi_5u4-qPlvxGL-vWvXeRGmPkKQJPeUeNesq62ntHhW5cuTZuqxH0rg-960Pv--iEtBc-y4q2_9B6lk3Gf92wd0u_oa-9a9xKd18oqV_mU_0s5snDNUgN_AesBHG9</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1613910393</pqid></control><display><type>article</type><title>Lycopodium Alkaloids from Huperzia serrata</title><source>Wiley Online Library Journals Frontfile Complete</source><creator>Ying, You-Min ; Liu, Xiao-Sa ; Tong, Cui-Ping ; Wang, Jian-Wei ; Zhan, Zha-Jun ; Shan, Wei-Guang</creator><creatorcontrib>Ying, You-Min ; Liu, Xiao-Sa ; Tong, Cui-Ping ; Wang, Jian-Wei ; Zhan, Zha-Jun ; Shan, Wei-Guang</creatorcontrib><description>Three new lycopodium alkaloids, huperserramines A–C (1–3, resp.), along with 15 known ones, lycopodine‐6α,11α‐diol (4), lycoposerramine H (5), lycoposerramine I (6), lycopodine‐6α‐ol (7), lycoposerramine M (8), diphaladine A (9), lycoposerramine K (10), lycoposerramine W (11), huperzine M (12), luciduline (13), phlegmariuine N (14), huperzine A (15), huperzine B (16), lycodine (17), and lycoposerramine R (18), were isolated from the whole plant of Huperzia serrata. Their structures were established by spectroscopic methods, including 2D‐NMR and MS analyses. All the isolates were evaluated for their inhibitory effects on acetylcholinesterase (AChE) and α‐glucosidase. As a result, lycopodine‐6α,11α‐diol (4) exhibited more potent α‐glucosidase inhibitory activity (IC50 148±5.5 μM) than the positive control acarbose (IC50 376.3±2.7 μM).</description><identifier>ISSN: 0018-019X</identifier><identifier>EISSN: 1522-2675</identifier><identifier>DOI: 10.1002/hlca.201400015</identifier><language>eng</language><publisher>Zürich: WILEY-VCH Verlag</publisher><subject>Acetylcholinesterase ; Alkaloids ; Huperzia serrata ; Lycopodium alkaloids ; α-Glucosidase</subject><ispartof>Helvetica chimica acta, 2014-10, Vol.97 (10), p.1433-1439</ispartof><rights>Copyright © 2014 Verlag Helvetica Chimica Acta AG, Zürich</rights><rights>Copyright © 2014 Verlag Helvetica Chimica Acta AG, Zurich</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3555-634d1a5d047a701842ac7d8f76eedb7eefa15948e6731e26485ece1c007f1bc43</citedby><cites>FETCH-LOGICAL-c3555-634d1a5d047a701842ac7d8f76eedb7eefa15948e6731e26485ece1c007f1bc43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fhlca.201400015$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fhlca.201400015$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids></links><search><creatorcontrib>Ying, You-Min</creatorcontrib><creatorcontrib>Liu, Xiao-Sa</creatorcontrib><creatorcontrib>Tong, Cui-Ping</creatorcontrib><creatorcontrib>Wang, Jian-Wei</creatorcontrib><creatorcontrib>Zhan, Zha-Jun</creatorcontrib><creatorcontrib>Shan, Wei-Guang</creatorcontrib><title>Lycopodium Alkaloids from Huperzia serrata</title><title>Helvetica chimica acta</title><addtitle>HCA</addtitle><description>Three new lycopodium alkaloids, huperserramines A–C (1–3, resp.), along with 15 known ones, lycopodine‐6α,11α‐diol (4), lycoposerramine H (5), lycoposerramine I (6), lycopodine‐6α‐ol (7), lycoposerramine M (8), diphaladine A (9), lycoposerramine K (10), lycoposerramine W (11), huperzine M (12), luciduline (13), phlegmariuine N (14), huperzine A (15), huperzine B (16), lycodine (17), and lycoposerramine R (18), were isolated from the whole plant of Huperzia serrata. Their structures were established by spectroscopic methods, including 2D‐NMR and MS analyses. All the isolates were evaluated for their inhibitory effects on acetylcholinesterase (AChE) and α‐glucosidase. As a result, lycopodine‐6α,11α‐diol (4) exhibited more potent α‐glucosidase inhibitory activity (IC50 148±5.5 μM) than the positive control acarbose (IC50 376.3±2.7 μM).</description><subject>Acetylcholinesterase</subject><subject>Alkaloids</subject><subject>Huperzia serrata</subject><subject>Lycopodium alkaloids</subject><subject>α-Glucosidase</subject><issn>0018-019X</issn><issn>1522-2675</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNqFkE1Lw0AQhhdRsFavngPehNSZ7G42OZaqrRAqgl-3ZbuZYNrUxN0Grb_elEjx5mlgeJ55mZexc4QRAkRXb5U1owhQAADKAzZAGUVhFCt5yAbdKgkB09djduL9skPSFNSAXWZbWzd1XrbrYFytTFWXuQ8KV6-DWduQ-y5N4Mk5szGn7Kgwlaez3zlkT7c3j5NZmN1P7ybjLLRcShnGXORoZA5CGdWlishYlSeFionyhSIqDMpUJBQrjhTFIpFkCS2AKnBhBR-yi_5u4-qPlvxGL-vWvXeRGmPkKQJPeUeNesq62ntHhW5cuTZuqxH0rg-960Pv--iEtBc-y4q2_9B6lk3Gf92wd0u_oa-9a9xKd18oqV_mU_0s5snDNUgN_AesBHG9</recordid><startdate>201410</startdate><enddate>201410</enddate><creator>Ying, You-Min</creator><creator>Liu, Xiao-Sa</creator><creator>Tong, Cui-Ping</creator><creator>Wang, Jian-Wei</creator><creator>Zhan, Zha-Jun</creator><creator>Shan, Wei-Guang</creator><general>WILEY-VCH Verlag</general><general>WILEY‐VCH Verlag</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope></search><sort><creationdate>201410</creationdate><title>Lycopodium Alkaloids from Huperzia serrata</title><author>Ying, You-Min ; Liu, Xiao-Sa ; Tong, Cui-Ping ; Wang, Jian-Wei ; Zhan, Zha-Jun ; Shan, Wei-Guang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3555-634d1a5d047a701842ac7d8f76eedb7eefa15948e6731e26485ece1c007f1bc43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Acetylcholinesterase</topic><topic>Alkaloids</topic><topic>Huperzia serrata</topic><topic>Lycopodium alkaloids</topic><topic>α-Glucosidase</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ying, You-Min</creatorcontrib><creatorcontrib>Liu, Xiao-Sa</creatorcontrib><creatorcontrib>Tong, Cui-Ping</creatorcontrib><creatorcontrib>Wang, Jian-Wei</creatorcontrib><creatorcontrib>Zhan, Zha-Jun</creatorcontrib><creatorcontrib>Shan, Wei-Guang</creatorcontrib><collection>Istex</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Helvetica chimica acta</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ying, You-Min</au><au>Liu, Xiao-Sa</au><au>Tong, Cui-Ping</au><au>Wang, Jian-Wei</au><au>Zhan, Zha-Jun</au><au>Shan, Wei-Guang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lycopodium Alkaloids from Huperzia serrata</atitle><jtitle>Helvetica chimica acta</jtitle><addtitle>HCA</addtitle><date>2014-10</date><risdate>2014</risdate><volume>97</volume><issue>10</issue><spage>1433</spage><epage>1439</epage><pages>1433-1439</pages><issn>0018-019X</issn><eissn>1522-2675</eissn><abstract>Three new lycopodium alkaloids, huperserramines A–C (1–3, resp.), along with 15 known ones, lycopodine‐6α,11α‐diol (4), lycoposerramine H (5), lycoposerramine I (6), lycopodine‐6α‐ol (7), lycoposerramine M (8), diphaladine A (9), lycoposerramine K (10), lycoposerramine W (11), huperzine M (12), luciduline (13), phlegmariuine N (14), huperzine A (15), huperzine B (16), lycodine (17), and lycoposerramine R (18), were isolated from the whole plant of Huperzia serrata. Their structures were established by spectroscopic methods, including 2D‐NMR and MS analyses. All the isolates were evaluated for their inhibitory effects on acetylcholinesterase (AChE) and α‐glucosidase. As a result, lycopodine‐6α,11α‐diol (4) exhibited more potent α‐glucosidase inhibitory activity (IC50 148±5.5 μM) than the positive control acarbose (IC50 376.3±2.7 μM).</abstract><cop>Zürich</cop><pub>WILEY-VCH Verlag</pub><doi>10.1002/hlca.201400015</doi><tpages>7</tpages></addata></record>
fulltext	fulltext
identifier	ISSN: 0018-019X
ispartof	Helvetica chimica acta, 2014-10, Vol.97 (10), p.1433-1439
issn	0018-019X 1522-2675
language	eng
recordid	cdi_proquest_journals_1613910393
source	Wiley Online Library Journals Frontfile Complete
subjects	Acetylcholinesterase Alkaloids Huperzia serrata Lycopodium alkaloids α-Glucosidase
title	Lycopodium Alkaloids from Huperzia serrata
url	https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-06T11%3A35%3A53IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Lycopodium%20Alkaloids%20from%20Huperzia%20serrata&rft.jtitle=Helvetica%20chimica%20acta&rft.au=Ying,%20You-Min&rft.date=2014-10&rft.volume=97&rft.issue=10&rft.spage=1433&rft.epage=1439&rft.pages=1433-1439&rft.issn=0018-019X&rft.eissn=1522-2675&rft_id=info:doi/10.1002/hlca.201400015&rft_dat=%3Cproquest_cross%3E3465317461%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1613910393&rft_id=info:pmid/&rfr_iscdi=true