CD4^sup +^ and CD8^sup +^ T cell-dependent antiviral immunity requires STIM1 and STIM2

Calcium signaling is critical for lymphocyte function, and intracellular Ca^sup 2+^ concentrations are regulated by store-operated Ca^sup 2+^ entry (SOCE) through Ca^sup 2+^ release-activated Ca^sup 2+^ (CRAC) channels. In patients, loss-of-function mutations in CRAC channel components ORAI1 and STI...

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Veröffentlicht in:	The Journal of clinical investigation 2014-10, Vol.124 (10), p.4549
Hauptverfasser:	Shaw, Patrick J, Weidinger, Carl, Vaeth, Martin, Luethy, Kevin, Kaech, Susan M, Feske, Stefan
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedical research Cytotoxicity Herpes viruses Immune system Infections Lymphocytes Multiple sclerosis Patients T cell receptors Viral infections
Online-Zugang:	Volltext
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