Fas/Fas Ligand Mediates Keratinocyte Death in Sunitinib-Induced Hand-Foot Skin Reaction

Sunitinib, a multitargeted receptor Y kinase inhibitor (TKI) used for the treatment of renal cell carcinoma and gastrointestinal stromal tumor (GIST), is notorious for cutaneous adverse effects, such as hand-foot skin reaction (HFSR). To explore the underlying mechanism of HFSR, we enrolled 53 sunit...

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Veröffentlicht in:	Journal of investigative dermatology 2014-11, Vol.134 (11), p.2768-2775
Hauptverfasser:	Yeh, Chun-Nan, Chung, Wen-Hung, Su, Shih-Chi, Chen, Yen-Yang, Cheng, Chi-Tung, Lin, Yen-Ling, Chang, Wan-Chun, Chung-Yee Hui, Rosaline, Chiang, Kun-Chun, Chen, Tsung-Wen, Jan, Yi-Yin, Chen, Chien-Wei, Chen, Ting-Jui, Yang, Chih-Hsun, Hung, Shuen-Iu
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Apoptosis Biomarkers - metabolism Biopsy Cell Death Cell Line, Tumor Disease Models, Animal Erythema - chemically induced Erythema - metabolism Fas Ligand Protein - blood Fas Ligand Protein - metabolism fas Receptor - metabolism Female Foot - pathology Gene Expression Regulation Hand - pathology Humans Indoles - chemistry Keratinocytes - cytology Keratinocytes - pathology Mice Mice, Inbred C3H Pyrroles - chemistry Time Factors
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