OX40 and IL‐7 play synergistic roles in the homeostatic proliferation of effector memory CD4+ T cells

T‐cell homeostasis preserves the numbers, the diversity and functional competence of different T‐cell subsets that are required for adaptive immunity. Naïve CD4+ T (TN) cells are maintained in the periphery via the common γ‐chain family cytokine IL‐7 and weak antigenic signals. However, it is not cl...

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Veröffentlicht in:	European journal of immunology 2014-10, Vol.44 (10), p.3015-3025
Hauptverfasser:	Yamaki, Satoshi, Ine, Shouji, Kawabe, Takeshi, Okuyama, Yuko, Suzuki, Nobu, Soroosh, Pejman, Mousavi, Seyed Fazlollah, Nagashima, Hiroyuki, Sun, Shu‐lan, So, Takanori, Sasaki, Takeshi, Harigae, Hideo, Sugamura, Kazuo, Kudo, Hironori, Wada, Motoshi, Nio, Masaki, Ishii, Naoto
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive Transfer Animals CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism Cell Proliferation - physiology Flow Cytometry Homeostasis - immunology Homeostatic proliferation Immunologic Memory - immunology Interleukin-7 - immunology Interleukin-7 - metabolism Memory CD4+ T cells Mice Mice, Inbred C57BL Mice, Transgenic OX40 Receptors, OX40 - immunology Receptors, OX40 - metabolism T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism Th17
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