Capn4 contributes to tumour growth and metastasis of hepatocellular carcinoma by activation of the FAK-Src signalling pathways

Calpain small subunit 1 (Capn4) has been identified as a major gene that promotes metastasis of hepatocellular carcinoma (HCC). However, the mechanism by which Capn4 promotes progression of HCC is not understood. In this study, we found that Capn4 expression was increased in highly metastatic HCC ce...

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Veröffentlicht in:	The Journal of pathology 2014-11, Vol.234 (3), p.316-328
Hauptverfasser:	Dai, Zhi, Zhou, Shao-Lai, Zhou, Zheng-Jun, Bai, Dou-Sheng, Xu, Xiao-Yu, Fu, Xiu-Tao, Chen, Qing, Zhao, Yi-Ming, Zhu, Kai, Yu, Lei, Yang, Guo-Huan, Wang, Zheng, Wu, Wei-Zhong, Zhou, Jian, Fan, Jia
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Animals Blotting, Western Calpain - metabolism calpain small subunit 1 Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - mortality Carcinoma, Hepatocellular - pathology Female Fluorescent Antibody Technique focal adhesion kinase Focal Adhesion Kinase 1 - metabolism hepatocellular carcinoma Heterografts Humans Immunoprecipitation Kaplan-Meier Estimate Liver Neoplasms - metabolism Liver Neoplasms - mortality Liver Neoplasms - pathology Male metastasis Mice Mice, Nude Microscopy, Confocal Middle Aged Neoplasm Invasiveness - pathology prognosis Proportional Hazards Models Signal Transduction - physiology src-Family Kinases - metabolism Tissue Array Analysis Transfection
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