Synthesis of Mono- and Dihydroxylated Amino Acids with New [alpha]-Ketoglutarate-Dependent Dioxygenases: Biocatalytic Oxidation of CH Bonds

Iron(II)/[alpha]-ketoacid-dependent oxygenases ([alpha]KAOs) are enzymes that mainly catalyse hydroxylation reaction. By using a genomic approach combining sequence comparison and protein-domain sharing, a set of 131 [alpha]KAO enzymes was prepared. The screening of various substrates revealed five...

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Veröffentlicht in:	ChemCatChem 2014-10, Vol.6 (10), p.3012
Hauptverfasser:	Baud, Damien, Saaidi, Pierre-Loïc, Monfleur, Adam, Harari, Marine, Cuccaro, Julien, Fossey, Aurélie, Besnard, Marielle, Debard, Adrien, Mariage, Aline, Pellouin, Virginie, Petit, Jean-Louis, Salanoubat, Marcel, Weissenbach, Jean, deBerardinis, Véronique, Zaparucha, Anne
Format:	Artikel
Sprache:	eng
Schlagworte:	Enzymes Oxidation
Online-Zugang:	Volltext
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