Efficacy and safety of triple therapy with aprepitant, palonosetron, and dexamethasone for preventing nausea and vomiting induced by cisplatin-based chemotherapy for gynecological cancer: KCOG-G1003 phase II trial

Purpose Prevention of chemotherapy-induced nausea and vomiting (CINV) is crucial for maintaining the quality of life of cancer patients. Female patients have been underrepresented in previous clinical studies of aprepitant or palonosetron. We performed a prospective multicenter study to investigate...

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Veröffentlicht in:	Supportive care in cancer 2014-11, Vol.22 (11), p.2891-2898
Hauptverfasser:	Takeshima, Nobuhiro, Matoda, Maki, Abe, Masakazu, Hirashima, Yasuyuki, Kai, Kentaro, Nasu, Kaei, Takano, Masashi, Furuya, Kenichi, Sato, Seiya, Itamochi, Hiroaki, Tsubamoto, Hiroshi, Hasegawa, Kosei, Terao, Kiminari, Otsuki, Takeo, Kuritani, Keiko, Ito, Kimihiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Activities of daily living Adult Aged Antiemetics - therapeutic use Antineoplastic Combined Chemotherapy Protocols - adverse effects Cancer Care and treatment Chemotherapy Cisplatin - administration & dosage Cisplatin - adverse effects Clinical trials Dexamethasone Dexamethasone - therapeutic use Drug therapy Drug Therapy, Combination Female Genital Neoplasms, Female - drug therapy Health aspects Humans Isoquinolines - therapeutic use Medicine Medicine & Public Health Middle Aged Morpholines - therapeutic use Nausea Nausea - chemically induced Nausea - prevention & control Neoplasms - drug therapy Nursing Nursing Research Oncology Original Article Pain Medicine Product development Prospective Studies Quality of Life Quinuclidines - therapeutic use Rehabilitation Medicine Side effects Vomiting - chemically induced Vomiting - prevention & control
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