Pharmacodynamics and Pharmacokinetics of a Novel, Low-Dose, Soft-Gel Capsule of Acetylsalicylic Acid in Comparison with an Oral Solution After Single-Dose Administration to Healthy Volunteers: A Phase I, Two-Way Crossover Study

Background Low-dose acetylsalicylic acid (ASA; aspirin) is well-established as a platelet anti-aggregating agent for the secondary prevention of cardiovascular events. Objectives The objective of this study was to investigate the non-inferiority of a novel ASA 75 mg soft-gel capsule formulation comp...

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Veröffentlicht in:	Clinical drug investigation 2014, Vol.34 (1), p.19-25
Hauptverfasser:	Loprete, Luca, Leuratti, Chiara, Scarsi, Claudia, Radicioni, Milko
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adult Aspirin - administration & dosage Aspirin - adverse effects Aspirin - pharmacokinetics Aspirin - pharmacology Capsules Cross-Over Studies Female Healthy Volunteers Humans Internal Medicine Male Medicine Medicine & Public Health Middle Aged Original Research Article Pharmacology/Toxicology Pharmacotherapy Platelet Aggregation - drug effects Platelet Aggregation Inhibitors - administration & dosage Platelet Aggregation Inhibitors - adverse effects Platelet Aggregation Inhibitors - pharmacokinetics Platelet Aggregation Inhibitors - pharmacology Solutions Therapeutic Equivalency Thromboxane B2 - antagonists & inhibitors Thromboxane B2 - blood Young Adult
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