The HIV protease inhibitor indinavir down-regulates the expression of the pro-angiogenic MT1-MMP by human endothelial cells

In addition to contrast human immunodeficiency virus (HIV) replication, the HIV protease inhibitors (HIV-PI) have reduced tumour incidence or clinical progression in infected patients. In this regard, we have previously shown that, independently of its anti-viral activity, the HIV-PI indinavir (IDV)...

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Veröffentlicht in:	Angiogenesis (London) 2014-10, Vol.17 (4), p.831-838
Hauptverfasser:	Barillari, Giovanni, Iovane, André, Bacigalupo, Ilaria, Labbaye, Catherine, Chiozzini, Chiara, Sernicola, Leonardo, Quaranta, Maria Teresa, Falchi, Mario, Sgadari, Cecilia, Ensoli, Barbara
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical and Life Sciences Biomedicine Brief Communication Cancer Research Cardiology Cell Biology Cell Nucleus - metabolism Chromatin Immunoprecipitation Endothelial Cells - metabolism Fibroblast Growth Factor 2 - metabolism Gene Expression Regulation, Enzymologic HIV Protease Inhibitors - chemistry Human Umbilical Vein Endothelial Cells Humans Indinavir - pharmacology Matrix Metalloproteinase 14 - metabolism Mice Mice, Nude Neovascularization, Pathologic Oncology Ophthalmology Promoter Regions, Genetic Real-Time Polymerase Chain Reaction Sp1 Transcription Factor - metabolism Vascular Endothelial Growth Factor A - metabolism
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