Mycophenolic Acid, Mycophenolate Mofetil, Mizoribine, Ribavirin, and 7-Nitroindole Inhibit Propagation of Babesia Parasites by Targeting Inosine 50-Monophosphate Dehydrogenase

The resistance of Babesia parasites to current anti-babesiosis drugs is an issue of major concern. The inosine 5'-monophosphate dehydrogenase (IMPDH) of Babesia gibsoni has been identified and characterized as a molecular drug target in our previous studies. In the present study, inhibitory eff...

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Veröffentlicht in:	The Journal of parasitology 2014-08, Vol.100 (4), p.522
Hauptverfasser:	Cao, Shinuo, Aboge, Gabriel Oluga, Terkawi, Mohamad Alaa, Zhou, Mo, Kamyingkird, Ketsarin, Moumouni, Paul Franck Adjou, Masatani, Tatsunori, Igarashi, Ikuo, Nishikawa, Yoshifumi, Suzuki, Hiroshi, Xuan, Xuenan
Format:	Artikel
Sprache:	eng
Schlagworte:	Carbon dioxide Dehydrogenase Dehydrogenases Drugs Enzymes Infections Laboratory animals Livestock industry Metabolism Metabolites Parasites
Online-Zugang:	Volltext
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