MC4R-expressing glutamatergic neurons in the paraventricular hypothalamus regulate feeding and are synaptically connected to the parabrachial nucleus

Significance Both in rodents and humans, melanocortin-4 receptors (MC4Rs) suppress appetite and prevent obesity. Unfortunately, the underlying neural mechanisms by which MC4Rs regulate food intake are poorly understood. Unraveling these mechanisms may open up avenues for treating obesity. In the pre...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2014-09, Vol.111 (36), p.13193-13198
Hauptverfasser:	Shah, Bhavik P., Vong, Linh, Olson, David P., Koda, Shuichi, Krashes, Michael J., Ye, Chianping, Yang, Zongfang, Fuller, Patrick M., Elmquist, Joel K., Lowell, Bradford B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals appetite Basic Helix-Loop-Helix Transcription Factors - metabolism Biological Sciences Body Weight Brain corticotropin-releasing hormone Dependovirus - metabolism Energy Metabolism Feeding Behavior Food intake GABAergic Neurons - metabolism Gene Deletion Gene expression Glutamates - metabolism Hormones humans Hyperphagia Injections Integrases - metabolism Mass Melanocortins Mice Neurons Neurons - metabolism Neuropeptides - metabolism Obesity oxytocin Parabrachial Nucleus - metabolism paraventricular hypothalamic nucleus Paraventricular Hypothalamic Nucleus - metabolism Receptor, Melanocortin, Type 4 - metabolism Receptors Repressor Proteins - metabolism Reproducibility of Results rodents Satiety Stereotaxic Techniques Synapses - metabolism vasopressin Vesicular Glutamate Transport Protein 2 - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!