Staphylococcus aureus secretes a unique class of neutrophil serine protease inhibitors

Significance Neutrophils are among the first immune cells to migrate to the site of infection and clear invading bacteria. They store large amounts of neutrophil serine proteases (NSPs) that play key roles in immune defense. Unfortunately, NSPs also contribute to tissue destruction in a variety of i...

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Veröffentlicht in:	Proc. Natl. Acad. Sci. USA 2014-09, Vol.111 (36), p.13187-13192
Hauptverfasser:	Stapels, Daphne A. C., Ramyar, Kasra X., Bischoff, Markus, Milder, Fin J., Ruyken, Maartje, Eisenbeis, Janina, McWhorter, William J., Herrmann, Mathias, van Kessel, Kok P. M., Geisbrecht, Brian V., Rooijakkers, Suzan H. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Active sites Animals Bacteria Bacterial Adhesion Bacterial Proteins - metabolism Biocatalysis Biological Sciences Crystal structure crystallography Employee assistance programs Extracellular Space - metabolism Female Gram-positive bacteria Humans immune response Infections Leukocyte Elastase - antagonists & inhibitors Leukocyte Elastase - metabolism Leukocytes Mice Mice, Inbred C57BL Models, Molecular Molecules Neutrophils Neutrophils - metabolism Pathogenesis pathogenicity Pathogens Protease inhibitors proteinase inhibitors Proteins Serine Proteinase Inhibitors - secretion serine proteinases Staphylococcal Infections - pathology Staphylococcus Staphylococcus aureus Staphylococcus aureus - metabolism
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