Subacute peripheral neuropathy under duodopa therapy without cobalamin deficiency and despite supplementation
Continuous jejunal levodopa infusion is an increasingly used therapy option in patients with Parkinson’s disease who experience severe fluctuations from oral levodopa. In a number of recent reports polyneuropathy in patients receiving jejunal levodopa infusion was referenced to cobalamin (vitamin B1...
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| Veröffentlicht in: | Journal of Neural Transmission 2014-10, Vol.121 (10), p.1269-1272 |
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| container_title | Journal of Neural Transmission |
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| creator | Lehnerer, Sophie M. Fietzek, Urban M. Messner, Michael Ceballos-Baumann, Andres O. |
| description | Continuous jejunal levodopa infusion is an increasingly used therapy option in patients with Parkinson’s disease who experience severe fluctuations from oral levodopa. In a number of recent reports polyneuropathy in patients receiving jejunal levodopa infusion was referenced to cobalamin (vitamin B12) deficiency. We describe one of three cases from our hospital with severe subacute polyneuropathy that developed during jejunal levodopa infusion, and occurred despite vitamin substitution therapy and normal vitamin B12 and holotranscobalamin serum levels. |
| doi_str_mv | 10.1007/s00702-014-1204-4 |
| format | Article |
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| ispartof | Journal of Neural Transmission, 2014-10, Vol.121 (10), p.1269-1272 |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Aged Antiparkinson Agents - administration & dosage Antiparkinson Agents - adverse effects Carbidopa - administration & dosage Carbidopa - adverse effects Drug Combinations Humans Infusions, Parenteral Jejunum Levodopa - administration & dosage Levodopa - adverse effects Male Medicine Medicine & Public Health Neurology Neurology and Preclinical Neurological Studies - Short communication Neurosciences Parkinson Disease - complications Parkinson Disease - drug therapy Parkinson Disease - physiopathology Polyneuropathies - chemically induced Polyneuropathies - drug therapy Polyneuropathies - physiopathology Psychiatry Vitamin B 12 - administration & dosage Vitamin B 12 - blood |
| title | Subacute peripheral neuropathy under duodopa therapy without cobalamin deficiency and despite supplementation |
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