Semi‐Mechanistic Modelling and Simulation of Inhibition of Platelet Aggregation by Antiplatelet Agents

Antiplatelet agents are a class of pharmaceuticals that decrease platelet aggregation and thus inhibit thrombus formation. We examined the relationships between plasma concentrations of antiplatelet agents (triflusal, clopidogrel and cilostazol) and the platelet aggregation inhibitory effect after d...

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Veröffentlicht in:	Basic & clinical pharmacology & toxicology 2014-10, Vol.115 (4), p.352-359
Hauptverfasser:	Yun, Hwi‐yeol, Kang, Wonku, Lee, Byung‐yo, Park, Sunkyung, Yoon, Young‐Ran, Yeul Ma, Jin, Kwon, Kwang‐il
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biological and medical sciences Blood Platelets - drug effects Drug therapy Half-Life Humans Medical sciences Models, Theoretical Pharmacology. Drug treatments Platelet Aggregation - drug effects Platelet Aggregation Inhibitors - administration & dosage Platelet Aggregation Inhibitors - blood Platelet Aggregation Inhibitors - pharmacokinetics Retrospective Studies Salicylates - administration & dosage Salicylates - blood Salicylates - pharmacokinetics Simulation Tetrazoles - administration & dosage Tetrazoles - blood Tetrazoles - pharmacokinetics Ticlopidine - administration & dosage Ticlopidine - analogs & derivatives Ticlopidine - blood Ticlopidine - pharmacokinetics Young Adult
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