TCF2 Attenuates FFA-Induced Damage in Islet [beta]-Cells by Regulating Production of Insulin and ROS

Free fatty acids (FFAs) are cytotoxic to pancreatic islet β-cells and play a crucial role in the diabetes disease process. A recent study revealed a down-regulation of transcription factor 2 (TCF2) levels during FFA-mediated cytotoxicity in pancreatic β-cells. However, its function during this proce...

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Veröffentlicht in:	International journal of molecular sciences 2014-08, Vol.15 (8), p.13317
Hauptverfasser:	Quan, Xiaojuan, Zhang, Lin, Li, Yingna, Liang, Chunlian
Format:	Artikel
Sprache:	eng
Schlagworte:	Cytotoxicity Fatty acids Pancreas Protein expression Signal transduction
Online-Zugang:	Volltext
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