p38 signaling inhibits mTORC1-independent autophagy in senescent human CD8^sup +^ T cells

T cell senescence is thought to contribute to immune function decline, but the pathways that mediate senescence in these cells are not clear. In this article, the researchers evaluated T cell populations from healthy volunteers and determined that human CD8^sup +^ effector memory T cells that reexpr...

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Veröffentlicht in:	The Journal of clinical investigation 2014-09, Vol.124 (9), p.4004
Hauptverfasser:	Henson, Sian M, Lanna, Alessio, Riddell, Natalie E, Franzese, Ornella, Macaulay, Richard, Griffiths, Stephen J, Puleston, Daniel J, Watson, Alexander Scarth, Simon, Anna Katharina, Tooze, Sharon A, Akbar, Arne N
Format:	Artikel
Sprache:	eng
Schlagworte:	Autophagy Biomedical research Cell division Cytokines Deoxyribonucleic acid DNA DNA damage Lymphocytes Medical research Phosphorylation Population Senescence Studies Telomerase
Online-Zugang:	Volltext
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