HSP90 inhibitor AUY922 abrogates up‐regulation of RTKs by mTOR inhibitor AZD8055 and potentiates its antiproliferative activity in human breast cancer

mTOR inhibition led to activation of upstream receptor tyrosine kinases (RTKs) and AKT, which may attenuate the efficacy of mTOR kinase inhibitors. We sought to discover efficient drug combination with mTOR inhibitors by elucidating the survival feedback loops induced by mTOR inhibition in breast ca...

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Veröffentlicht in:	International journal of cancer 2014-11, Vol.135 (10), p.2462-2474
Hauptverfasser:	Chen, Si‐Meng, Guo, Chen‐Liang, Shi, Jia‐Jie, Xu, Yi‐Chao, Chen, Yi, Shen, Yan‐Yan, Su, Yi, Ding, Jian, Meng, Ling‐Hua
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Blotting, Western Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Breast Neoplasms - pathology Cancer Cell cycle Cell Proliferation drug combination Drug Synergism Female HSP90 Heat-Shock Proteins - antagonists & inhibitors HSP90 inhibitor Humans Immunoenzyme Techniques Isoxazoles - pharmacology Kinases Medical research Mice Mice, Inbred BALB C Mice, Nude Morpholines - pharmacology mTOR kinase inhibitor Protein Transport Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Real-Time Polymerase Chain Reaction receptor tyrosine kinases Resorcinols - pharmacology Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics TOR Serine-Threonine Kinases - antagonists & inhibitors Tumor Cells, Cultured
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