A General and Practical Synthesis of N-Aryl-3-[4-(imidazol-4-yl)-1,2,3-triazol-1-yl]benzamide Anti-Inflammatory Cytokine Inhibitors
A practical, safe, and efficient synthesis of anti‐inflammatory cytokine inhibitors was developed and implemented for a number of analogues. A key aspect of the process is an efficient, one‐pot, tandem copper‐catalyzed azidonation and Huisgen 1,3‐dipolar cycloaddition using silyl protected alkynes....
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| Veröffentlicht in: | Asian journal of organic chemistry 2014-07, Vol.3 (7), p.769-772 |
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| container_title | Asian journal of organic chemistry |
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| creator | Frutos, Rogelio P. Rodriguez, Sonia Patel, Nitinchandra D. Reeves, Diana Tampone, Thomas Senanayake, Chris H. |
| description | A practical, safe, and efficient synthesis of anti‐inflammatory cytokine inhibitors was developed and implemented for a number of analogues. A key aspect of the process is an efficient, one‐pot, tandem copper‐catalyzed azidonation and Huisgen 1,3‐dipolar cycloaddition using silyl protected alkynes.
Couple and click: A practical, safe, and efficient synthesis of N‐aryl‐3‐[4‐(imidazol‐4‐yl)‐1,2,3‐triazol‐1‐yl]benzamide anti‐inflammatory cytokine inhibitors was developed and implemented for a number of analogues. A key aspect of the process is an efficient, one‐pot, tandem copper‐catalyzed azidonation and Huisgen 1,3‐dipolar cycloaddition using silyl protected alkynes. |
| doi_str_mv | 10.1002/ajoc.201400002 |
| format | Article |
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Couple and click: A practical, safe, and efficient synthesis of N‐aryl‐3‐[4‐(imidazol‐4‐yl)‐1,2,3‐triazol‐1‐yl]benzamide anti‐inflammatory cytokine inhibitors was developed and implemented for a number of analogues. A key aspect of the process is an efficient, one‐pot, tandem copper‐catalyzed azidonation and Huisgen 1,3‐dipolar cycloaddition using silyl protected alkynes.</description><identifier>ISSN: 2193-5807</identifier><identifier>EISSN: 2193-5815</identifier><identifier>DOI: 10.1002/ajoc.201400002</identifier><language>eng</language><publisher>Weinheim: WILEY-VCH Verlag</publisher><subject>3-dipolar cycloaddition ; click chemistry ; copper ; cytokine inhibitors ; Cytokines ; Huisgen 1 ; Huisgen 1,3‐dipolar cycloaddition ; Organic chemistry ; triazoles</subject><ispartof>Asian journal of organic chemistry, 2014-07, Vol.3 (7), p.769-772</ispartof><rights>2014 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3552-95d8bcdeea971b2e51775ec8400c78cd453e4667cdd865ca0c9e2e5fdbcb92913</citedby><cites>FETCH-LOGICAL-c3552-95d8bcdeea971b2e51775ec8400c78cd453e4667cdd865ca0c9e2e5fdbcb92913</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fajoc.201400002$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fajoc.201400002$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids></links><search><creatorcontrib>Frutos, Rogelio P.</creatorcontrib><creatorcontrib>Rodriguez, Sonia</creatorcontrib><creatorcontrib>Patel, Nitinchandra D.</creatorcontrib><creatorcontrib>Reeves, Diana</creatorcontrib><creatorcontrib>Tampone, Thomas</creatorcontrib><creatorcontrib>Senanayake, Chris H.</creatorcontrib><title>A General and Practical Synthesis of N-Aryl-3-[4-(imidazol-4-yl)-1,2,3-triazol-1-yl]benzamide Anti-Inflammatory Cytokine Inhibitors</title><title>Asian journal of organic chemistry</title><addtitle>Asian Journal of Organic Chemistry</addtitle><description>A practical, safe, and efficient synthesis of anti‐inflammatory cytokine inhibitors was developed and implemented for a number of analogues. A key aspect of the process is an efficient, one‐pot, tandem copper‐catalyzed azidonation and Huisgen 1,3‐dipolar cycloaddition using silyl protected alkynes.
Couple and click: A practical, safe, and efficient synthesis of N‐aryl‐3‐[4‐(imidazol‐4‐yl)‐1,2,3‐triazol‐1‐yl]benzamide anti‐inflammatory cytokine inhibitors was developed and implemented for a number of analogues. A key aspect of the process is an efficient, one‐pot, tandem copper‐catalyzed azidonation and Huisgen 1,3‐dipolar cycloaddition using silyl protected alkynes.</description><subject>3-dipolar cycloaddition</subject><subject>click chemistry</subject><subject>copper</subject><subject>cytokine inhibitors</subject><subject>Cytokines</subject><subject>Huisgen 1</subject><subject>Huisgen 1,3‐dipolar cycloaddition</subject><subject>Organic chemistry</subject><subject>triazoles</subject><issn>2193-5807</issn><issn>2193-5815</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNqFkM1LwzAYh4soKOrVc8GLgplN0izNsRSdk-H3x0EkpOlbzOxSTSpar_7jZk6GN3NJ8uN53pBfFO3gZICThByqaasHJMFpEhZZiTYIFhSxDLPV5Tnh69G299M5wrnARGxEX3k8AgtONbGyVXzhlO6MDrfr3nZP4I2P2zo-Q7nrG0TRQ4r2zMxU6rNtUIr6Zh_hA3JAUefMT4ZD9liC_VSBgji3nUFjWzdqNlNd6_q46Lv22ViIx_bJlCZkfitaq1XjYft334xuj49uihM0OR-Ni3yCNGWMIMGqrNQVgBIclwQY5pyBzsKXNc90lTIK6XDIdVVlQ6ZVogUEqq5KXQoiMN2MdhdzX1z7-ga-k9P2zdnwpMSMiTCVYRqowYLSrvXeQS1fnJkp10ucyHnXct61XHYdBLEQ3k0D_T-0zE_Pi78uWrjGd_CxdJV7lkNOOZP3ZyMpLtPiik6IvKPf2H6RGg</recordid><startdate>201407</startdate><enddate>201407</enddate><creator>Frutos, Rogelio P.</creator><creator>Rodriguez, Sonia</creator><creator>Patel, Nitinchandra D.</creator><creator>Reeves, Diana</creator><creator>Tampone, Thomas</creator><creator>Senanayake, Chris H.</creator><general>WILEY-VCH Verlag</general><general>WILEY‐VCH Verlag</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>201407</creationdate><title>A General and Practical Synthesis of N-Aryl-3-[4-(imidazol-4-yl)-1,2,3-triazol-1-yl]benzamide Anti-Inflammatory Cytokine Inhibitors</title><author>Frutos, Rogelio P. ; Rodriguez, Sonia ; Patel, Nitinchandra D. ; Reeves, Diana ; Tampone, Thomas ; Senanayake, Chris H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3552-95d8bcdeea971b2e51775ec8400c78cd453e4667cdd865ca0c9e2e5fdbcb92913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>3-dipolar cycloaddition</topic><topic>click chemistry</topic><topic>copper</topic><topic>cytokine inhibitors</topic><topic>Cytokines</topic><topic>Huisgen 1</topic><topic>Huisgen 1,3‐dipolar cycloaddition</topic><topic>Organic chemistry</topic><topic>triazoles</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Frutos, Rogelio P.</creatorcontrib><creatorcontrib>Rodriguez, Sonia</creatorcontrib><creatorcontrib>Patel, Nitinchandra D.</creatorcontrib><creatorcontrib>Reeves, Diana</creatorcontrib><creatorcontrib>Tampone, Thomas</creatorcontrib><creatorcontrib>Senanayake, Chris H.</creatorcontrib><collection>Istex</collection><collection>CrossRef</collection><jtitle>Asian journal of organic chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Frutos, Rogelio P.</au><au>Rodriguez, Sonia</au><au>Patel, Nitinchandra D.</au><au>Reeves, Diana</au><au>Tampone, Thomas</au><au>Senanayake, Chris H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A General and Practical Synthesis of N-Aryl-3-[4-(imidazol-4-yl)-1,2,3-triazol-1-yl]benzamide Anti-Inflammatory Cytokine Inhibitors</atitle><jtitle>Asian journal of organic chemistry</jtitle><addtitle>Asian Journal of Organic Chemistry</addtitle><date>2014-07</date><risdate>2014</risdate><volume>3</volume><issue>7</issue><spage>769</spage><epage>772</epage><pages>769-772</pages><issn>2193-5807</issn><eissn>2193-5815</eissn><abstract>A practical, safe, and efficient synthesis of anti‐inflammatory cytokine inhibitors was developed and implemented for a number of analogues. A key aspect of the process is an efficient, one‐pot, tandem copper‐catalyzed azidonation and Huisgen 1,3‐dipolar cycloaddition using silyl protected alkynes.
Couple and click: A practical, safe, and efficient synthesis of N‐aryl‐3‐[4‐(imidazol‐4‐yl)‐1,2,3‐triazol‐1‐yl]benzamide anti‐inflammatory cytokine inhibitors was developed and implemented for a number of analogues. A key aspect of the process is an efficient, one‐pot, tandem copper‐catalyzed azidonation and Huisgen 1,3‐dipolar cycloaddition using silyl protected alkynes.</abstract><cop>Weinheim</cop><pub>WILEY-VCH Verlag</pub><doi>10.1002/ajoc.201400002</doi><tpages>4</tpages></addata></record> |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | 3-dipolar cycloaddition click chemistry copper cytokine inhibitors Cytokines Huisgen 1 Huisgen 1,3‐dipolar cycloaddition Organic chemistry triazoles |
| title | A General and Practical Synthesis of N-Aryl-3-[4-(imidazol-4-yl)-1,2,3-triazol-1-yl]benzamide Anti-Inflammatory Cytokine Inhibitors |
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