Differences in the regulation of RyR2 from human, sheep, and rat by Ca^sup 2+^ and Mg^sup 2+^ in the cytoplasm and in the lumen of the sarcoplasmic reticulum

Regulation of the cardiac ryanodine receptor (RyR2) by intracellular Ca... and Mg... plays a key role in determining cardiac contraction and rhythmicity, but their role in regulating the human RyR2 remains poorly defined. The Ca...- and Mg...-dependent regulation of human RyR2 was recorded in artifi...

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Veröffentlicht in:	The Journal of general physiology 2014-09, Vol.144 (3), p.263
Hauptverfasser:	Walweel, Kafa, Li, Jiao, Molenaar, Peter, Imtiaz, Mohammad S, Quail, Anthony, dos Remedios, Cris G, Beard, Nicole A, Dulhunty, Angela F, van Helden, Dirk F, Laver, Derek R
Format:	Artikel
Sprache:	eng
Schlagworte:	Calcium Cytoplasm Human subjects Magnesium Physiology Rodents Sheep
Online-Zugang:	Volltext
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