TheAutographa californicanuclear polyhedrosis virus AcNPV induces functional maturation of human monocyte-derived dendritic cells
The initiation of an adaptive immune response is critically dependent on the activation of dendritic cells (DCs). Therefore, vaccination strategies targeting DCs have to ensure a proper presentation of the immunogen as well as an activation of DCs to accomplish their full maturation. Viral vectors c...
Gespeichert in:
| Veröffentlicht in: | Vaccine 2006-11, Vol.24 (49-50), p.7190 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 49-50 |
| container_start_page | 7190 |
| container_title | Vaccine |
| container_volume | 24 |
| creator | Schütz, Alexandra Scheller, Nicoletta Breinig, Tanja Meyerhans, Andreas |
| description | The initiation of an adaptive immune response is critically dependent on the activation of dendritic cells (DCs). Therefore, vaccination strategies targeting DCs have to ensure a proper presentation of the immunogen as well as an activation of DCs to accomplish their full maturation. Viral vectors can achieve gene delivery and a subsequent presentation of the expressed immunogen, however, the immunization efficiency may be hampered by an inhibition of DC activation. Here we report that the insect bornAutographa californicanuclear polyhedrosis virus (AcNPV), which is already used for genetic immunization, is able to activate human monocyte-derived DCs. This activation induces the production of tumor necrosis factor alpha (TNF-α), an up-regulation of the surface molecules CD83, CD80, CD86, HLA-DR and HLA-I and increases the T cell stimulatory capacity of DCs. Thus, AcNPV represents a promising vector for vaccine trials. |
| doi_str_mv | 10.1016/j.vaccine.2006.06.044 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest</sourceid><recordid>TN_cdi_proquest_journals_1559079418</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3420768701</sourcerecordid><originalsourceid>FETCH-proquest_journals_15590794183</originalsourceid><addsrcrecordid>eNqNjM1KxDAURoM4YHV8BOGC69akf9MuB1FciYtB3A3h5tampEnNT2GWvrkO-ADCB4cDh4-xO8ELwUX7MBWrRNSWipLztjivri9YJrpdlZeN6C5Zxsu2zmvBP67YdQgT57ypRJ-x78NI-xTdp5fLKAGl0YPzVqO0CQ1JD4szp5GUd0EHWLVPAfb4-vYO2qqEFGBIFqN2VhqYZUxengXcAGOapYXZWYenSLkir1dSoMgqr6NGQDImbNlmkCbQ7R9v2P3z0-HxJV-8-0oU4nFyyf--h6Nomp7v-lp01f-qHwipW8k</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1559079418</pqid></control><display><type>article</type><title>TheAutographa californicanuclear polyhedrosis virus AcNPV induces functional maturation of human monocyte-derived dendritic cells</title><source>Elsevier ScienceDirect Journals Complete - AutoHoldings</source><source>ProQuest Central UK/Ireland</source><creator>Schütz, Alexandra ; Scheller, Nicoletta ; Breinig, Tanja ; Meyerhans, Andreas</creator><creatorcontrib>Schütz, Alexandra ; Scheller, Nicoletta ; Breinig, Tanja ; Meyerhans, Andreas</creatorcontrib><description>The initiation of an adaptive immune response is critically dependent on the activation of dendritic cells (DCs). Therefore, vaccination strategies targeting DCs have to ensure a proper presentation of the immunogen as well as an activation of DCs to accomplish their full maturation. Viral vectors can achieve gene delivery and a subsequent presentation of the expressed immunogen, however, the immunization efficiency may be hampered by an inhibition of DC activation. Here we report that the insect bornAutographa californicanuclear polyhedrosis virus (AcNPV), which is already used for genetic immunization, is able to activate human monocyte-derived DCs. This activation induces the production of tumor necrosis factor alpha (TNF-α), an up-regulation of the surface molecules CD83, CD80, CD86, HLA-DR and HLA-I and increases the T cell stimulatory capacity of DCs. Thus, AcNPV represents a promising vector for vaccine trials.</description><identifier>ISSN: 0264-410X</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/j.vaccine.2006.06.044</identifier><language>eng</language><publisher>Kidlington: Elsevier Limited</publisher><subject>Cloning ; Flow cytometry ; Genes ; HIV ; Human immunodeficiency virus ; Immune response ; Immune system ; Immunization ; Infections ; Lymphocytes ; Vaccines</subject><ispartof>Vaccine, 2006-11, Vol.24 (49-50), p.7190</ispartof><rights>Copyright Elsevier Limited Nov 30, 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1559079418?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,64384,64388,72340</link.rule.ids></links><search><creatorcontrib>Schütz, Alexandra</creatorcontrib><creatorcontrib>Scheller, Nicoletta</creatorcontrib><creatorcontrib>Breinig, Tanja</creatorcontrib><creatorcontrib>Meyerhans, Andreas</creatorcontrib><title>TheAutographa californicanuclear polyhedrosis virus AcNPV induces functional maturation of human monocyte-derived dendritic cells</title><title>Vaccine</title><description>The initiation of an adaptive immune response is critically dependent on the activation of dendritic cells (DCs). Therefore, vaccination strategies targeting DCs have to ensure a proper presentation of the immunogen as well as an activation of DCs to accomplish their full maturation. Viral vectors can achieve gene delivery and a subsequent presentation of the expressed immunogen, however, the immunization efficiency may be hampered by an inhibition of DC activation. Here we report that the insect bornAutographa californicanuclear polyhedrosis virus (AcNPV), which is already used for genetic immunization, is able to activate human monocyte-derived DCs. This activation induces the production of tumor necrosis factor alpha (TNF-α), an up-regulation of the surface molecules CD83, CD80, CD86, HLA-DR and HLA-I and increases the T cell stimulatory capacity of DCs. Thus, AcNPV represents a promising vector for vaccine trials.</description><subject>Cloning</subject><subject>Flow cytometry</subject><subject>Genes</subject><subject>HIV</subject><subject>Human immunodeficiency virus</subject><subject>Immune response</subject><subject>Immune system</subject><subject>Immunization</subject><subject>Infections</subject><subject>Lymphocytes</subject><subject>Vaccines</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNjM1KxDAURoM4YHV8BOGC69akf9MuB1FciYtB3A3h5tampEnNT2GWvrkO-ADCB4cDh4-xO8ELwUX7MBWrRNSWipLztjivri9YJrpdlZeN6C5Zxsu2zmvBP67YdQgT57ypRJ-x78NI-xTdp5fLKAGl0YPzVqO0CQ1JD4szp5GUd0EHWLVPAfb4-vYO2qqEFGBIFqN2VhqYZUxengXcAGOapYXZWYenSLkir1dSoMgqr6NGQDImbNlmkCbQ7R9v2P3z0-HxJV-8-0oU4nFyyf--h6Nomp7v-lp01f-qHwipW8k</recordid><startdate>20061130</startdate><enddate>20061130</enddate><creator>Schütz, Alexandra</creator><creator>Scheller, Nicoletta</creator><creator>Breinig, Tanja</creator><creator>Meyerhans, Andreas</creator><general>Elsevier Limited</general><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7T2</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope></search><sort><creationdate>20061130</creationdate><title>TheAutographa californicanuclear polyhedrosis virus AcNPV induces functional maturation of human monocyte-derived dendritic cells</title><author>Schütz, Alexandra ; Scheller, Nicoletta ; Breinig, Tanja ; Meyerhans, Andreas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_journals_15590794183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Cloning</topic><topic>Flow cytometry</topic><topic>Genes</topic><topic>HIV</topic><topic>Human immunodeficiency virus</topic><topic>Immune response</topic><topic>Immune system</topic><topic>Immunization</topic><topic>Infections</topic><topic>Lymphocytes</topic><topic>Vaccines</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schütz, Alexandra</creatorcontrib><creatorcontrib>Scheller, Nicoletta</creatorcontrib><creatorcontrib>Breinig, Tanja</creatorcontrib><creatorcontrib>Meyerhans, Andreas</creatorcontrib><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nursing & Allied Health Database</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><jtitle>Vaccine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schütz, Alexandra</au><au>Scheller, Nicoletta</au><au>Breinig, Tanja</au><au>Meyerhans, Andreas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>TheAutographa californicanuclear polyhedrosis virus AcNPV induces functional maturation of human monocyte-derived dendritic cells</atitle><jtitle>Vaccine</jtitle><date>2006-11-30</date><risdate>2006</risdate><volume>24</volume><issue>49-50</issue><spage>7190</spage><pages>7190-</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><abstract>The initiation of an adaptive immune response is critically dependent on the activation of dendritic cells (DCs). Therefore, vaccination strategies targeting DCs have to ensure a proper presentation of the immunogen as well as an activation of DCs to accomplish their full maturation. Viral vectors can achieve gene delivery and a subsequent presentation of the expressed immunogen, however, the immunization efficiency may be hampered by an inhibition of DC activation. Here we report that the insect bornAutographa californicanuclear polyhedrosis virus (AcNPV), which is already used for genetic immunization, is able to activate human monocyte-derived DCs. This activation induces the production of tumor necrosis factor alpha (TNF-α), an up-regulation of the surface molecules CD83, CD80, CD86, HLA-DR and HLA-I and increases the T cell stimulatory capacity of DCs. Thus, AcNPV represents a promising vector for vaccine trials.</abstract><cop>Kidlington</cop><pub>Elsevier Limited</pub><doi>10.1016/j.vaccine.2006.06.044</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0264-410X |
| ispartof | Vaccine, 2006-11, Vol.24 (49-50), p.7190 |
| issn | 0264-410X 1873-2518 |
| language | eng |
| recordid | cdi_proquest_journals_1559079418 |
| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; ProQuest Central UK/Ireland |
| subjects | Cloning Flow cytometry Genes HIV Human immunodeficiency virus Immune response Immune system Immunization Infections Lymphocytes Vaccines |
| title | TheAutographa californicanuclear polyhedrosis virus AcNPV induces functional maturation of human monocyte-derived dendritic cells |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-09T07%3A32%3A04IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=TheAutographa%20californicanuclear%20polyhedrosis%20virus%20AcNPV%20induces%20functional%20maturation%20of%20human%20monocyte-derived%20dendritic%20cells&rft.jtitle=Vaccine&rft.au=Sch%C3%BCtz,%20Alexandra&rft.date=2006-11-30&rft.volume=24&rft.issue=49-50&rft.spage=7190&rft.pages=7190-&rft.issn=0264-410X&rft.eissn=1873-2518&rft_id=info:doi/10.1016/j.vaccine.2006.06.044&rft_dat=%3Cproquest%3E3420768701%3C/proquest%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1559079418&rft_id=info:pmid/&rfr_iscdi=true |