AttenuatedSalmonella typhimurium htrAmutants cause fatal infections in mice deficient in NADPH oxidase and destroy NADPH oxidase-deficient macrophage monolayers

Salmonellalive vaccine strains harbouring mutations inhtrA, a stress protein gene, display increased susceptibility to oxidative stress in vitro. This is believed to be connected to their reduced virulence, perhaps due to impaired survival inside phagocytes, although this has never been formally pro...

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Veröffentlicht in:	Vaccine 2004-09, Vol.22 (29-30), p.4124
Hauptverfasser:	Mutunga, Mbithe, Graham, Sarah, de Hormaeche, Raquel Demarco, Musson, Julie A, Robinson, John H, Mastroeni, Pietro, Khan, CMAnjam, Hormaeche, Carlos E
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacteria Bacterial infections Bone marrow Deoxyribonucleic acid DNA Experiments Genes Hydrogen peroxide Infections Oxidative stress Salmonella Vaccines
Online-Zugang:	Volltext
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