Kunjin replicon-based simian immunodeficiency virusgagvaccines
An RNA-based, non-cytopathic replicon vector system, based on the flavivirus Kunjin, has shown considerable promise as a new vaccine delivery system. Here we describe the testing in mice of four different SIVmac239gagvaccines delivered by Kunjin replicon virus-like-particles. The four vaccines encod...
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| Veröffentlicht in: | Vaccine 2008-06, Vol.26 (26), p.3268 |
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| container_title | Vaccine |
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| creator | Anraku, Itaru Mokhonov, Vladislav V Rattanasena, Paweena Mokhonova, Ekaterina I Leung, Jason Pijlman, Gorben Cara, Andrea Schroder, Wayne A Khromykh, Alexander A Suhrbier, Andreas |
| description | An RNA-based, non-cytopathic replicon vector system, based on the flavivirus Kunjin, has shown considerable promise as a new vaccine delivery system. Here we describe the testing in mice of four different SIVmac239gagvaccines delivered by Kunjin replicon virus-like-particles. The four vaccines encoded the wild typegaggene, an RNA-optimisedgaggene, a codon-optimisedgaggene and a modifiedgag-polgene construct. The vaccines behaved quite differently for induction of effector memory and central memory responses, for mediation of protection, and with respect to insert stability, with the SIVgag-polvaccine providing the optimal performance. These results illustrate that for an RNA-based vector the RNA sequence of the antigen can have profound and unforeseen consequences on vaccine behaviour. |
| doi_str_mv | 10.1016/j.vaccine.2008.04.001 |
| format | Article |
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| ispartof | Vaccine, 2008-06, Vol.26 (26), p.3268 |
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| language | eng |
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| source | Access via ScienceDirect (Elsevier); ProQuest Central UK/Ireland |
| subjects | Acquired immune deficiency syndrome AIDS Construction Genes HIV Human immunodeficiency virus Infections Plasmids Proteins RNA polymerase Vaccines Viruses |
| title | Kunjin replicon-based simian immunodeficiency virusgagvaccines |
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