Pseudomonas aeruginosa adaptation in the nasopharyngeal reservoir leads to migration and persistence in the lungs
Chronic bacterial infections are a key feature of a variety of lung conditions. The opportunistic bacterium, Pseudomonas aeruginosa , is extremely skilled at both colonizing and persisting in the airways of patients with lung damage. It has been suggested that the upper airways (including the parana...
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| Veröffentlicht in: | Nature communications 2014-09, Vol.5 (1), p.4780, Article 4780 |
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| creator | Fothergill, Joanne L. Neill, Daniel R. Loman, Nick Winstanley, Craig Kadioglu, Aras |
| description | Chronic bacterial infections are a key feature of a variety of lung conditions. The opportunistic bacterium,
Pseudomonas aeruginosa
, is extremely skilled at both colonizing and persisting in the airways of patients with lung damage. It has been suggested that the upper airways (including the paranasal sinuses and nasopharynx) play an important role as a silent reservoir of bacteria. Over time,
P. aeruginosa
can adapt to its niche, leading to increased resistance in the face of the immune system and intense therapy regimes. Here we describe a mouse inhalation model of
P. aeruginosa
chronic infection that can be studied for at least 28 days. We present evidence for adaptation
in vivo
, in terms of genotype and phenotype including antibiotic resistance. Our data suggest that there is persistence in the upper respiratory tract and that this is key in the establishment of lung infection. This model provides a unique platform for studying evolutionary dynamics and therapeutics.
Pseudomonas aeruginosa
causes chronic infections in patients with lung damage. Here, Fothergill
et al
. develop an intranasal inhalation model of
P. aeruginosa
infection and describe genetic and phenotypic changes that the bacteria undergo during adaptation and spread through the respiratory tract. |
| doi_str_mv | 10.1038/ncomms5780 |
| format | Article |
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Pseudomonas aeruginosa
, is extremely skilled at both colonizing and persisting in the airways of patients with lung damage. It has been suggested that the upper airways (including the paranasal sinuses and nasopharynx) play an important role as a silent reservoir of bacteria. Over time,
P. aeruginosa
can adapt to its niche, leading to increased resistance in the face of the immune system and intense therapy regimes. Here we describe a mouse inhalation model of
P. aeruginosa
chronic infection that can be studied for at least 28 days. We present evidence for adaptation
in vivo
, in terms of genotype and phenotype including antibiotic resistance. Our data suggest that there is persistence in the upper respiratory tract and that this is key in the establishment of lung infection. This model provides a unique platform for studying evolutionary dynamics and therapeutics.
Pseudomonas aeruginosa
causes chronic infections in patients with lung damage. Here, Fothergill
et al
. develop an intranasal inhalation model of
P. aeruginosa
infection and describe genetic and phenotypic changes that the bacteria undergo during adaptation and spread through the respiratory tract.</description><identifier>ISSN: 2041-1723</identifier><identifier>EISSN: 2041-1723</identifier><identifier>DOI: 10.1038/ncomms5780</identifier><identifier>PMID: 25179232</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/250/255/1318 ; 631/326/41/2529 ; 64 ; 64/60 ; 692/699/1785 ; Adaptation, Physiological - genetics ; Administration, Inhalation ; Administration, Intranasal ; Amino Acid Sequence ; Animals ; Anti-Bacterial Agents - pharmacology ; Bacterial Proteins - genetics ; Bacterial Proteins - metabolism ; Base Sequence ; Biofilms - growth & development ; Colony Count, Microbial ; Disease Models, Animal ; Female ; Gene Expression Regulation, Bacterial ; Genotype ; Host-Pathogen Interactions ; Humanities and Social Sciences ; Humans ; Lung - microbiology ; Lung - pathology ; Mice ; Mice, Inbred BALB C ; Molecular Sequence Data ; multidisciplinary ; Nasopharynx - microbiology ; Nasopharynx - pathology ; Paranasal Sinuses - microbiology ; Paranasal Sinuses - pathology ; Phenotype ; Polymorphism, Single Nucleotide ; Pseudomonas aeruginosa - drug effects ; Pseudomonas aeruginosa - genetics ; Pseudomonas aeruginosa - pathogenicity ; Pseudomonas Infections - drug therapy ; Pseudomonas Infections - microbiology ; Pseudomonas Infections - pathology ; Science ; Science (multidisciplinary)</subject><ispartof>Nature communications, 2014-09, Vol.5 (1), p.4780, Article 4780</ispartof><rights>Springer Nature Limited 2014</rights><rights>Copyright Nature Publishing Group Sep 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c387t-466ecf65d1950c11e2768c8d7a11b1dd73f7777a5eaef0306ea5961d399e99f13</citedby><cites>FETCH-LOGICAL-c387t-466ecf65d1950c11e2768c8d7a11b1dd73f7777a5eaef0306ea5961d399e99f13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/ncomms5780$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://doi.org/10.1038/ncomms5780$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41120,42189,51576</link.rule.ids><linktorsrc>$$Uhttps://doi.org/10.1038/ncomms5780$$EView_record_in_Springer_Nature$$FView_record_in_$$GSpringer_Nature</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25179232$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fothergill, Joanne L.</creatorcontrib><creatorcontrib>Neill, Daniel R.</creatorcontrib><creatorcontrib>Loman, Nick</creatorcontrib><creatorcontrib>Winstanley, Craig</creatorcontrib><creatorcontrib>Kadioglu, Aras</creatorcontrib><title>Pseudomonas aeruginosa adaptation in the nasopharyngeal reservoir leads to migration and persistence in the lungs</title><title>Nature communications</title><addtitle>Nat Commun</addtitle><addtitle>Nat Commun</addtitle><description>Chronic bacterial infections are a key feature of a variety of lung conditions. The opportunistic bacterium,
Pseudomonas aeruginosa
, is extremely skilled at both colonizing and persisting in the airways of patients with lung damage. It has been suggested that the upper airways (including the paranasal sinuses and nasopharynx) play an important role as a silent reservoir of bacteria. Over time,
P. aeruginosa
can adapt to its niche, leading to increased resistance in the face of the immune system and intense therapy regimes. Here we describe a mouse inhalation model of
P. aeruginosa
chronic infection that can be studied for at least 28 days. We present evidence for adaptation
in vivo
, in terms of genotype and phenotype including antibiotic resistance. Our data suggest that there is persistence in the upper respiratory tract and that this is key in the establishment of lung infection. This model provides a unique platform for studying evolutionary dynamics and therapeutics.
Pseudomonas aeruginosa
causes chronic infections in patients with lung damage. Here, Fothergill
et al
. develop an intranasal inhalation model of
P. aeruginosa
infection and describe genetic and phenotypic changes that the bacteria undergo during adaptation and spread through the respiratory tract.</description><subject>631/250/255/1318</subject><subject>631/326/41/2529</subject><subject>64</subject><subject>64/60</subject><subject>692/699/1785</subject><subject>Adaptation, Physiological - genetics</subject><subject>Administration, Inhalation</subject><subject>Administration, Intranasal</subject><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Bacterial Proteins - genetics</subject><subject>Bacterial Proteins - metabolism</subject><subject>Base Sequence</subject><subject>Biofilms - growth & development</subject><subject>Colony Count, Microbial</subject><subject>Disease Models, Animal</subject><subject>Female</subject><subject>Gene Expression Regulation, Bacterial</subject><subject>Genotype</subject><subject>Host-Pathogen Interactions</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Lung - 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The opportunistic bacterium,
Pseudomonas aeruginosa
, is extremely skilled at both colonizing and persisting in the airways of patients with lung damage. It has been suggested that the upper airways (including the paranasal sinuses and nasopharynx) play an important role as a silent reservoir of bacteria. Over time,
P. aeruginosa
can adapt to its niche, leading to increased resistance in the face of the immune system and intense therapy regimes. Here we describe a mouse inhalation model of
P. aeruginosa
chronic infection that can be studied for at least 28 days. We present evidence for adaptation
in vivo
, in terms of genotype and phenotype including antibiotic resistance. Our data suggest that there is persistence in the upper respiratory tract and that this is key in the establishment of lung infection. This model provides a unique platform for studying evolutionary dynamics and therapeutics.
Pseudomonas aeruginosa
causes chronic infections in patients with lung damage. Here, Fothergill
et al
. develop an intranasal inhalation model of
P. aeruginosa
infection and describe genetic and phenotypic changes that the bacteria undergo during adaptation and spread through the respiratory tract.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>25179232</pmid><doi>10.1038/ncomms5780</doi><oa>free_for_read</oa></addata></record> |
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| ispartof | Nature communications, 2014-09, Vol.5 (1), p.4780, Article 4780 |
| issn | 2041-1723 2041-1723 |
| language | eng |
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| source | Springer Nature OA Free Journals |
| subjects | 631/250/255/1318 631/326/41/2529 64 64/60 692/699/1785 Adaptation, Physiological - genetics Administration, Inhalation Administration, Intranasal Amino Acid Sequence Animals Anti-Bacterial Agents - pharmacology Bacterial Proteins - genetics Bacterial Proteins - metabolism Base Sequence Biofilms - growth & development Colony Count, Microbial Disease Models, Animal Female Gene Expression Regulation, Bacterial Genotype Host-Pathogen Interactions Humanities and Social Sciences Humans Lung - microbiology Lung - pathology Mice Mice, Inbred BALB C Molecular Sequence Data multidisciplinary Nasopharynx - microbiology Nasopharynx - pathology Paranasal Sinuses - microbiology Paranasal Sinuses - pathology Phenotype Polymorphism, Single Nucleotide Pseudomonas aeruginosa - drug effects Pseudomonas aeruginosa - genetics Pseudomonas aeruginosa - pathogenicity Pseudomonas Infections - drug therapy Pseudomonas Infections - microbiology Pseudomonas Infections - pathology Science Science (multidisciplinary) |
| title | Pseudomonas aeruginosa adaptation in the nasopharyngeal reservoir leads to migration and persistence in the lungs |
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